ZAD zinc finger-associated domain ZF zinc finger Zincon 2-carboxy-2′-hydroxy-5′-sulfoformazyl-benzene monosodium salt 1. Introduction The significant fraction of proteins utilizes cofactors in order to meet cellular requirements. Transition metal ions are the honorable examples, as life depends on...
B Full length Rag1 protein consists the functional important zinc-binding dimerization domain (ZDD) containing the RING finger (RING) and the zinc finger A (ZFA) as well as the c-terminal core domain with the nonamer-binding region (NBR) and the zinc finger B (ZFB). Mutated Rag1 lost...
Hennemann, H., Vassen, L., Geisen, C., Eilers, M., & Moroy, T. (2003). Identification of a novel Kruppel-associated box domain protein, Krim-1, that interacts with c-Myc and inhibits its oncogenic activity.The Journal of Biological Chemistry, 278, 28799–28811. PubMedCASGoogle Schola...
611 bp, leading to a protein comprising 537 aa. The molecular weight and isoelectric point calculated for PxZNF266 are 62.14 kDa and 8.70. Functional analyses suggest that PxZNF266 possesses both the ZnF_C2H2 and zf-AD domains
C4 zinc finger factors can be further classified into several subgroups, such as zinc fingers ZZ (ZZZ), zinc fingers AN1 (ZFAND) and GATA zinc-finger domain-containing (GATAD) types. GATAs,PPARsandDNA methyltransferases(DNMTs) have a C4 zinc finger motif(s). In addition, variousnuclear ...
The capability to manipulate and alter the various organisms has been one of the supreme achievements of modern molecular biologists. Custom designed zinc finger proteins (ZFPs) provide a powerful platform technology since other functional domains like non-specificFokI cleavage domain (N), transcription...
GATAD1 (GATA ZNF domain-containing protein 1, also known as ODAG, ocular development-associated gene) contains a ZNF domain at the N terminus12, and is located on chromosomal region 7q21–q22 (ref. 13). GWAS have implicated GATAD1 as a gene associated with adult height14,15. GATAD1 ...
SETDB1 and ZFPs are known to collaborate to suppress genomic regions including endogenous retroviruses (ERVs) [2, 22, 38, 39]. Krüppel-associated box domain ZFPs (KRAB- ZFPs, KZFPs), which are the largest subset of the C2H2-ZFP Fig. 4 Reduction of H3K9me3 at the C2H2-ZFP ...
For our MD simulations, we focused on two different systems: a) the zinc-finger domain ZF1 of the yeast Npl4 (Npl4(Zn2+)129–151, residues 129–151), and b) a construct without the UBXL N-terminal domain (residues 1–76) and the disordered linker (residues 77–112) of Npl4 (...
This class of peptides is involved in several cellular processes, and they can be found in proteins as a single functional domain, coupled with other zinc fingers or associated with other independent domains [45,46,47]. The consensus sequence (Y/F)-X-C-X2,4-C-X3-X-L-X2-H-X3,4-H...