Function genetics to use the zinc finger proteinThe present invention provides methods of regulating gene expression using recombinant zinc finger proteins, for functional genomics and target validation applications.ケイス キャシー シー.チャン レイ...
Complexity is one of the hallmarks that applies to C2H2 type zinc finger proteins (ZFPs). Structurally distinct clusters of zinc finger modules define an e
Along its linear polypeptide sequence, the full-length SALL4 protein (SALL4A) has three C2H2-type ZFCs (ZFC2–ZFC4) either in pairs or in a triplet, as well as one C2HC-type zinc finger. Zinc finger motifs are frequently associated with nucleic acid binding (Struhl, 1989); however, ...
zinc finger protein名词解释zinc fingerprotein名词解释 锌指蛋白是一类广泛存在于真核生物中的结构域蛋白,其特征性结构由锌离子与半胱氨酸、组氨酸残基共同配位形成稳定的“指状”折叠构象。这种独特的三维结构最早在非洲爪蟾卵母细胞转录因子ⅢA中发现,其周期性重复的锌结合模块与DNA双螺旋沟槽产生特异性结合作用,成为...
植物C2H2型锌指蛋白的结构与功能 热度: species-specific expansion of c2h2 zinc-finger genes and their expression profiles in silkworm bombyx mori:种c2h2锌指基因的特异性表达谱扩展和家蚕,家蚕 热度: 紫穗槐C2H2型锌指蛋白家族基因鉴定及逆境敏感性研究_ 热度: 相关推荐...
(Laity et al., 2001). The zinc ion serves to stabilize the integration of the protein itself, and is generally not involved in binding targets. The “finger” refers to the secondary structures (α-helix and β-sheet) that are held together by the Zn ion. Zinc finger containing domains ...
finger motif, Cys-X2/4-Cys-X12-His-X3–5-His. Therefore, each of these repeats contains two invariant pairs of cysteine andhistidineresidues, which coordinate a single atom of zinc and hold the antiparallelβ-sheet andα-helices of the protein in a compact globular structure. This results ...
纯化方法Protein A purified 目标详细情况 别名ZNF84 背景ZNF84, a gene located on chromosome 12, encodes a zinc finger protein whose function is undescribed. 分子量85 kDa 基因ID7637 NCBI登录号NP_003419, NM_003428 UniProtP51523 研究领域Chromatin and Nuclear Signaling, Transcription Factors ...
Metastasis is one of the most common reasons of hepatocellular carcinoma (HCC) death; however, the molecular mechanism underlying HCC metastasis remains incompletely defined. Here we report a new function of Zinc Finger Protein 703 (ZNF703), a member of
The most important and abundant types of zinc-finger domain proteins include C2H2, really interesting new gene (RING), plant homeodomain (PHD), and Lin-ll, Isl-1, and Mec-3 (LIM domains). Their protein structures are presented in Figure 1a. Among C2H2 ZNFs, there are a large number of...