PROBLEM TO BE SOLVED: To provide a method of identifying the biological function of a candidate gene.SOLUTION: The method includes the steps of: (i) selecting a first candidate gene; (ii) providing a first zinc finger protein that binds to a first target site of the first candidate gene ...
Along its linear polypeptide sequence, the full-length SALL4 protein (SALL4A) has three C2H2-type ZFCs (ZFC2–ZFC4) either in pairs or in a triplet, as well as one C2HC-type zinc finger. Zinc finger motifs are frequently associated with nucleic acid binding (Struhl, 1989); however, ...
These proteins function as transcriptional factors to regulate the target gene transcription. Some zinc finger proteins such as LIM-ZF, MYND-ZF, PHD-ZF and RING-ZF, function as the protein adaptors to mediate the protein-protein interaction. Additionally, some of zinc finger proteins can interact...
Zinc finger (ZF) motifs are protein domains containing typically 30–40 amino acid residues, whose structures are maintained by coordination of Zn(II) ions to side chain donors of histidine and/or cysteine residues in a tetrahedral geometry. ...
型锌指蛋白是最多也是研究最为清楚的 一类锌指蛋白$在植物中已经克隆了 H’ 多个$主要涉及植物的生长发育和对环境胁迫的应答反应’该类锌指蛋白 大部分在锌指区具有植物中特有的 JKLMMI 保守结构$可能涉及调控植物特有的生物学功能’文章主要讨论了 植物 >!I! 型锌指转录因子的结构(对靶 N6K 的识别及在生长发育...
zinc finger hit domain-containing protein 作用zinc finger hit domain-containing protein作用具体如下: 调控基因表达。最早被发现的锌指结构域蛋白是转录因子,它通过与DNA结合来调控基因表达。 参与免疫应答。在免疫系统中,锌指结构域蛋白参与了对病原体的识别和免疫应答。 参与细胞周期调控、细胞凋亡、DNA修复和信号...
Zinc Finger Protein 57 (ZFP57) (C-Term) 抗体 公司简介 上海钰博生物科技有限公司是2012年5月由“海归”组成的创业团队与两个专业投资机构发起成立的,以开发生产科研试剂和特色检验产品为方向,经过两年多的努力,已经建立了免疫学和分子生物学的五个技术平台,开发了ELISA/ELISpot酶联免疫试剂盒、重组蛋白、荧光标...
The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. In order to clarify its molecular mechanism of action, we used the yeast two-hybrid system to screen for proteins that interact with A20. A cDNA ... D Valck,Dirk,Jin,... - ...
tof encodes a forebrain-specific zinc finger transcription repressor that is homologous to the mammalian Fezl (forebrain embryonic zinc finger–like protein). Mosaic and co-staining analyses showed that fezl was not expressed in DA or 5HT neurons and instead controlled development of these neurons ...
Twitter Google Share on Facebook zinc (redirected fromZinc finger protein) Thesaurus Medical Acronyms Encyclopedia Wikipedia zinc (zĭngk) n.SymbolZn A bluish-white, lustrous metallic element that is brittle at room temperature but malleable with heating. It is used to form a wide variety of al...