Given the wide variety of zinc-finger domains, ZNFs are able to interact with DNA, RNA, PAR (poly-ADP-ribose) and other proteins. Thus, ZNFs are involved in the regulation of several cellular processes. In fact, ZNFs are implicated in transcriptional regulation, ubiquitin- mediated protein ...
Zinc finger antisense 1 (ZFAS1), a newly identified long non-coding RNA, is a transcript antisense to the 5' end of the protein-coding gene zinc finger NFX1-type containing 1 which hosts three C/D-box small nucleolar RNAs (SNORDs) within sequential introns: Snord12, Snord12b, and S...
Zinc-finger proteins (ZNFs) are one of the most abundant groups of proteins and have a wide range of molecular functions. Given the wide variety of zinc-finger domains, ZNFs are able to interact with DNA, RNA, PAR (poly-ADP-ribose) and other proteins. Th
Zinc Finger Nucleases (ZFNs) are a programmable DNA binding protein system composed of zinc finger proteins fused to a bacterial nuclease. They enable site-specific double stranded DNA breaks for gene editing by recognizing specific DNA sequences within the genome. ...
[VIR])8,11, and HAKAI (also known as Casitas B-lineage lymphoma-transforming sequence-like protein 1 (CBLL1), plant homolog HAKAI)8,11, and in animals it also contains and requires RNA binding motif protein 15 (RBM15) and the zinc finger CCCH domain-containing protein 13 (ZC3H13)12,...
Recently, CtBP-interacting BTB Zinc Finger Protein (CIBZ) was identified as a key transcriptional regulator of ESCs and was shown to play a role in G1/S transition partly depending on Nanog expression (Nishii et al., 2012). Moreover, ZFP57 was shown to maintain the genomic imprints in ...
antisense TE sequences that hybridize with the TE RNA in the germ line and the soma resulting in the degradation of the TE RNA.17–19 Both of these mechanisms, the purging of deleterious insertions of TEs by means of natural selection and the production of repressors using antisense sequence...
Promyelocytic leukemia zinc finger (PLZF) is a transcription repressor that was initially isolated as a fusion protein with retinoic acid receptor α. PLZF is aberrantly overexpressed in various human solid tumors, such as clear cell renal carcinoma, glioblastoma, and seminoma. PLZF causes cellular ...
Conceptually, the accumulation of zinc-finger (ZF) motifs for high-affinity binding is similar to that of transcription factors (TFs) that are composed of ZF arrays. For example, the essential insulator protein CTCF has eleven ZFs29, and KRAB-ZF proteins feature twelve ZFs on average30. The ...
Effect of lentivirus-mediated RNA interference of APC … znt2-mediated zinc import into paneth cell granules is necessary for coordinated have secretion and paneth cell function in mice Review article Zinc finger protein (ZFP) in plants-A review Relationship between telomerase activity and...