In conclusion, zinc has anti-viral properties and is important in defending against respiratory viral infections and regulating the immune response in the respiratory tract.doi:10.1007/s12011-021-02859-zSadeghsoltani, FatemehMohammadzadeh, Iraj
Enteroviruses and the pathogenesis of type 1 diabetes revisited: cross-reactivity of enterovirus capsid protein (VP1) antibodies with human mitochondrial p... Current or recent enteroviral infections show an association with type 1 diabetes. However, evidence for this has mainly been generated using ...
Respiratory syncytial virus Reduction in viral titer and plaque count ZnCl2, Zn(OAc)2, Zn(Lac)2 0.01–10 mM (72) Rhinovirus Inhibition of viral polyprotein cleavage ZnCl2 100–800 μM (73, 74) Inhibition of viral polyprotein cleavage ZnCl2 0.1–1.2 mM (61) Inhibition of viral polymerase ...
In particular, the zinc-finger protein ZCCHC3 was recognized as interaction partners of the SARS-CoV-2 N protein. ZCCHC3 is a Cys2HisCys-protein that binds RNA and enables the recognition of intracellular RNA viruses activating anti-viral response mediated by IFNα-induced signalling and ...
finger (ZnFn2). An engineered ZnFn2 mutant cell line by CRISPR–Cas9 reveals that mutation of one allele of the GATA3 second zinc finger (ZnFn2) leads to loss of binding and decreased expression at a subset of genes, including Progesterone Receptor. At other loci, associated with epithelial...
Here, we use a genome-wide interference screen to determine invasion-essential genes and identify the AN1/A20 zinc finger domain containing protein 3 (ZFAND3) as a crucial driver of GBM invasion. Using patient-derived cellular models, we show that loss of ZFAND3 hampers the invasive capacity...
ArticleThe zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation Author links open overlay panelWenjie Zhang 1 2 7, Guangyan Zhangyuan 1 2 7, Fei Wang 1 2 7, Kangpeng Jin 1 2, Haiyuan Shen 1 2, Liansheng Zhang 3 4, ...
Functions of RING finger proteins are mediated through DNA binding and include the regulation of gene expression, DNA recombination, and DNA repair. The murine BMI-1 gene encodes a protein of 324 amino acids. This protein, which is found in the nuclei of a variety of normal cells, contains...
Design of TATA Box-Binding Protein/Zinc Finger Fusions for Targeted Regulation of Gene Expression, ;: 3616-3620 (1997). Liu, et al., “Design of Polydactyl Zinc-Finger Proteins for Unique Addressing within Complex Genomes”, Proc. Natl. Acad. Sci. USA 94: 5525-5530 (1997). ;: 5525-...
The C2HC Zn finger and linker are essential for RING-UbcH5a interactions. To obtain insights into how the C2HC ZnF (and Li2120-128) enhance RNF125 activity, we performed NMR titration experiments that allow a sensitive detection of protein-protein interactions and an identification of the ...