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The ZnuACB transporter usually consists of three parts, including the periplasmic Zn2+-binding protein ZnuA, the inner membrane channel protein ZnuB and the ATP enzyme protein ZnuC, which is responsible for providing energy for Zn2+transport [21]. ZinT and ZnuA have been shown to cooperate ...
24 Rho/Rac Guanine Nucleotide Exchange Factor 2 (ARHGEF2) and Actin-Binding LIM Protein 1 (ABLIM1) are associated with the cytoskeleton, and Paxillin with ZNF185 is localized to focal adhesion sites.25 The zinc-finger domain is one of the most frequently utilized DNA-binding motif found in...
Phytates may impair absorption by chelation and formation of insoluble complexes at an alkaline pH. After absorption, zinc is bound in the intestine to the protein metallothionein. Endogenous zinc can be reabsorbed in the ileum and colon, creating an enteropancreatic circulation of zinc. Volume ...
product ZnT1, found in all investigated tissues, and ZnT4 appear to be responsible for pumping excess zinc out of the cell. ZnT2 and ZnT3 sequester zinc into intracellular storage compartments in the intestine, kidney and testies, and in the synaptic vesicles of zinc-containing neurons, ...
Cysteine-rich intestinal protein (CRIP) is a newly identified peptide that occurs primarily in the intestine and binds zinc in the mucosa during absorption. High dietary zinc does not affect CRIP concentration, but it greatly increases metallothionein, which may compete with CRIP to decrease zinc ab...
Selenium is transported from the intestine via blood by transport proteins to the liver and other tissues. Selenoprotein P and extracellular GSH-Px have been identified in the plasma. Selenoprotein-P, a selenocystine-containing plasma protein, has been isolated in the rat and appears to function as...
Intestine ZNF proteins are also involved in intestinal epithelium biology. For example, in addition to its well-documented role in skin homeostasis, KLF4 also has a key role in the intestines. In this tissue, KLF4 is expressed in the terminally differentiated epithelial cells (luminal surface) and...
There is an increasing body of evidence indicating that zinc transport proteins play crucial roles in a variety of biological events. The Zrt, Irt-like protein/solute carrier family 39 (ZIP/SLC39A) and Zn transporter (ZnT)/SLC30A family are proteins that are primarily involved in zinc transpo...
Approximately 20% to 80% of zinc from food is absorbed in the duodenum and upper small intestine. Unabsorbed zinc, as well as zinc secreted into the gastrointestinal tract, is excreted in the feces. Approximately 2% of ingested zinc is excreted in the urine. Thus, homeostasis of zinc in the...