为探究草酸性肾病的发病机制,许艳芳教授团队构建了草酸盐诱导的急性肾损伤小鼠模型,发现敲除坏死样凋亡的核心信号分子ZBP1/RIPK3/MLKL能显著逆转小鼠肾脏损伤。在机制上,作者发现草酸钙刺激肾小管上皮细胞诱导氧化应激致线粒体损伤释放Z-m...
ZBP1 或 RIPK3 缺陷导致 SARS-CoV-2 在体外和体内感染期间炎症细胞因子和趋化因子的产生减少。此外,在受感染的小鼠模型中,删除 ZBP1 或 RIPK3 可减轻 SARS-CoV-2 感染引起的免疫细胞浸润和肺损伤。这些结果表明,ZBP1-RIPK3 通路在 SARS-CoV-2 诱导的炎症反应和肺损伤中起着关键作用。我们的研究为 SARS-...
Further evidence showed that ASFV infection upregulates the expression of ZBP1 and RIPK3 to consist of the ZBP1-RIPK3-MLKL necrosome and further activates macrophage necroptosis. Subsequently, multiple Z-DNA sequences were predicted to be present in the ASFV genome. The...
Genetic ablation of mice for up to 3 mo beyond parturition. Together, these studies implicate ZBP1 as the dominant activator of IFN-driven RIPK3 activation and perinatal lethality in the absence of RIPK1. Copyright 2019 by The American Association of Immunologists, Inc....
The formation of Z-DNA and its co-localization with Z-DNA binding protein (ZBP1) was observed due to the nuclear envelope damage by IF. Western blot, qPCR, IHC and IF confirmed Z-DNA-induced inflammation in AVICs through the ZBP1-RIPK3-NF-魏B signaling pathway. ZBP1 and RIPK3 ...
Z-DNA binding protein 1 (ZBP1) has important functions in anti-viral immunity and in the regulation of inflammatory responses. ZBP1 induces necroptosis by directly engaging and activating RIPK3, however, the mechanisms by which ZBP1 induces inflammation and in particular the role of RIPK1 and ...
This process activates Z-DNA binding protein 1 (ZBP1), which then interacts with receptor-interacting protein kinase 3 (RIPK3), ultimately leading to RIPK3-dependent necroptotic and ferroptotic signaling cascades. Specific deletion of eitherorin endothelial cells simultaneously inhibits both ...
Z-DNA binding protein 1 (ZBP1) has important functions in anti-viral immunity and in the regulation of inflammatory responses. ZBP1 induces necroptosis by directly engaging and activating RIPK3, however, the mechanisms by which ZBP1 induces inflammation and in particular the role of RIPK1 and ...
We found that neuronal ZIKV infection activated the nucleotide sensor ZBP1 and the kinases RIPK1 and RIPK3, core components of virus-induced necroptotic cell death signaling. However, activation of this pathway in ZIKV-infected neurons did not induce cell death. Rather, RIPK signaling restricted...
www.nature.com/cdd ARTICLE OPEN ZBP1 causes inflammation by inducing RIPK3-mediated necroptosis and RIPK1 kinase activity-independent apoptosis Lioba Koerner1,2, Laurens Wachsmuth1,2, Snehlata Kumari 1,2,4, Robin Schwarzer1,2,5, Theresa Wagner 1,2, Huipeng Jiao 1,2,6 and Manolis Pasp...