Moreover, MTT, qPCR, western blot, cell cycle analysis, and migration assays showed that inhibition of HDAC2 reduced YY1 expression, similarly, depletion of YY1 using knockdown approach inhibited the proliferation, migration, invasion, and blockage of the cell cycle by suppressing c‐Myc in lung ...
YY1 interacts directly or indirectly with many key proteins including the components of 1) RNA polymerase II transcription machineries, such as RNA polymerase II, TFIIB, TBP and TAFII55, 2) transcription factors, such as Sp1, c-myc, c-myb and CREB, and 3) histone-modifying complexes, such...
NM003403 -8 pcDNA3.1/MycHisA 全长 C-His、C-Myc 哺乳细胞 2800 NM003403 -9 pCMV-Tag 2A 全长 N-Flag 哺乳细胞 2800 NM003403 -10 pCMV-Tag 4A 全长 C-Flag 哺乳细胞 2800 NM003403 -11 pCMV-HA 全长 N-HA 哺乳细胞 2800 NM003403 -145447 pEGFP-C1 全长 N-EGFP 哺乳细胞 2800 NM003403...
Since YY1 downregulates C/EBPα expression through a promoter-dependent manner in HCC cells (26) and C/EBPα leads to upregulation of miR-34a expression during granulocytic differentiation (27), we aimed to ascertain whether or not YY1 regulates miR-34a expression via C/EBPα in human RCC. ...
We noticed that the early deregulated genes after loss of CTCF and cohesin include many cell-type-specific TFs (for example, Sox21, Myc and Klf4; Fig. 3i and Extended Data Fig. 5f). Chromatin structures around the DEGs were strongly disrupted, often featuring loss of a boundary or domain ...
AUSTEN, M., CERNI, C., LUSCHER-FIRZLAFF, J.M. and LUSCHER, B., YY1 can inhibit c-Myc function through a mechanism requiring DNA binding of YY1 but neither its transactivation domain nor direct interaction with c-Myc. Oncogene, 17, 511-520 (1998)....
结果表明,在各组K562细胞中均检测到DLL4、YY1和c-Myc蛋白的表达,实验组的DLL4、YY1和c-Myc蛋白表达量比两个对照组显著增多(p<0.05);实验组K562细胞的生长速度明显低于对照组;实验组较对照组G0/G1期细胞增多(p<0.001),凋亡率增加(p<0.001).结论:DLL4基因能增加细胞转录因子YY1和原癌基因c-Myc蛋白的...
Sankar N, Baluchamy S, Kadeppagari RK, Singhal G, Weitzman S, Thimmapaya B (2008) p300 provides a corepressor function by cooperating with YY1 and HDAC3 to repress c-Myc. Oncogene 27(43):5717–5728 View ArticleNadimMahmud, BenjaminPetro, SudhakarBaluchamy, XinminLi, SimonaTaioli, Donald...
Furthermore, SMURF2 could induce ubiquitination-mediated degradation of YY1, which bound to the SENP1 promoter and upregulated SENP1 expression, leading to enhancement of c-myc expression. The in vivo data revealed the suppressive role of SMURF2 gain-of-function in tumor growth through ...
C.HenrikssonHilfenhausS.Luscher-FirzlaffJ.M.ingentaconnectCurrent Topics in Microbiology & ImmunologyAusten M,Cerni C,Henriksson M,et al.Regulation of cell growth by the Myc-Max-Mad network: role of Mad proteins and YY1. Current Topics in Microbiology and Immunology . 1997...