Moreover, MTT, qPCR, western blot, cell cycle analysis, and migration assays showed that inhibition of HDAC2 reduced YY1 expression, similarly, depletion of YY1 using knockdown approach inhibited the proliferation, migration, invasion, and blockage of the cell cycle by suppressing c‐Myc in lung ...
BAF与YY1的相互作用一方面进一步加强了YY1的转录促进作用,另一方面,BAF的加入改变了YY1对多能性的调控机制,使得原本在多能性调控中YY1依赖的Myc通路转为依赖于Core通路(通过调控多能性基因Oct4、Nanog、Sall4等)。YY1、BAF和OCT4的相互作用使得该蛋白复合物不仅大量富集于启动子区域,还富集于超级增强子区域(下图)...
YY1 contains four zinc finger motifs of the Cys-Cys-His-His type and can activate different eukaryotic genes (such as CREB, c-myc, Histone H4, p53 and PARP-1) or repress different eukaryotic genes (such as α-actin, IFN-β and IFN-γ) as well as regulate some viral promoters (1)....
YY1 contains four zinc finger motifs of the Cys-Cys-His-His type and can activate different eukaryotic genes (such as CREB, c-myc, Histone H4, p53 and PARP-1) or repress different eukaryotic genes (such as α-actin, IFN-β and IFN-γ) as well as regulate some viral promoters (1)....
contributing to the expression of cell type-specific genes [5,6,7]. Importantly, YY1 is able to interact with a number of RNA molecules, such as long noncoding RNAs (lncRNAs) [8,9,10], and proteins, including HDACs [11,12], c-Myc [13], CTCF [14], p53 [15], Sp1 [16], and...
YY1 interacts directly or indirectly with many key proteins including the components of 1) RNA polymerase II transcription machineries, such as RNA polymerase II, TFIIB, TBP and TAFII55, 2) transcription factors, such as Sp1, c-myc, c-myb and CREB, and 3) histone-modifying complexes, such...
YY1 is constitutively expressed and is known to interact with other proteins involved in transcriptional regulation, such as c-Myc (31), Sp1 (32, 33), CREB/ATF (34), and NF-κB (35). YY1 has been shown to be involved in suppression of the interferon-γ (IFN-γ) promoter in T cells...
PARP2則可加強KAP1轉錄抑制活性但KAP1不影響PARP2在細胞中的分布.此外,PARP2與轉錄因子YY1具有交互作用且可加強YY1 在c-myc promoter (YY1 target promoter) 上... 許巧雨,Chiao-Yu Hsu - 《中興大學分子生物學研究所學位論文》 被引量: 0发表: 2008年 ...
Analysis of the regulation of YY1 localization in vitro demonstrated that polymerized γ-actin sequestered EGFP-YY1 in the cytoplasm and that YY1 activation of c- myc promoter activity was inhibited by LIM kinase, which increases actin polymerization. Consistent with these data siRNA-mediated down-...
NM003403 -8 pcDNA3.1/MycHisA 全长 C-His、C-Myc 哺乳细胞 2800 NM003403 -9 pCMV-Tag 2A 全长 N-Flag 哺乳细胞 2800 NM003403 -10 pCMV-Tag 4A 全长 C-Flag 哺乳细胞 2800 NM003403 -11 pCMV-HA 全长 N-HA 哺乳细胞 2800 NM003403 -145447 pEGFP-C1 全长 N-EGFP 哺乳细胞 2800 NM003403...