The YTH domain binds to a short, degenerated, single-stranded RNA sequence motif. Binding to the RNA causes aggregation of YT521-B protein. The results show that the presence of the binding motif in alternative exons is necessary for YT521-B to directly influence splice site selection in ...
Like YTHDF1, the Pho92 YTH domain bound to m6A RNA without obvious sequence preference (Table 1). However, Tyr397 of YTHDF1 corresponded to Ser163 in Pho92 (Figs. 1A, 3D, and 6A); thus Pho92 would potentially recognize the nucleotide at −1 position with a pocket different from ...
Genome-Wide Identification and Expression Analysis of Members in the YT521-B Homology Domain-Containing RNA Binding Protein Family in Ginkgo bilobaGENETIC regulationRNA modification & restrictionRNA-binding proteinsABSCISIC acidGENE expressionN6-methyladenosine (m6A) is a widespread post-transcriptional ...