It is believed that reciprocal interactions between YAP1 activity in CAFs and tissue stiffness and mechanical stress in the tumor microenvironment drive a continuous process of maintaining CAF phenotypes and malignancy [10]. Previously, we showed that YAP1 is highly expressed in the nuclei of CAFs ...
Cellular experiments and animal studies further validated this conclusion.#This single-cell analysis uncovered the functional roles of CAFs in liver cancer. TheYAP1-positive CAF subpopulation, in particular, was shown to contribute to matrix stiffness by upregulating the expression of relevant genes and...
EEM and motif assays revealed that YAP1, collaborating with PITX2 transcriptional factor (TF), regulates TGF-beta-induced EMT and CAF, suggesting the involvement of YAP1 and PITX2 in the partial-EMT process, which was reported to play an important role in the nodal metastases of HNC (...
We hypothesized that YAP1 regulates the differentiation of dermal fibroblasts into highly contractile myofibroblasts and that YAP1 governs the maintenance of a myofibroblast phenotype in primary Dupuytren cells. Knockdown of YAP1 in transforming growth factor-β1–stimulated dermal fibroblasts decreased the...
Early dissemination, metastasis and therapy resistance are central hallmarks of aggressive cancer types and the leading cause of cancer-associated deaths. The EMT-inducing transcriptional repressor ZEB1 is a crucial stimulator of these processes, particu
Notably, one subset requires Pap1 nuclear accumulation but not its oxidation, and includes genes related to multidrug resistance like caf5, which encodes an efflux pump to exclude drugs from the intracellular compartment. The second subset includes antioxidant genes such as catalase and thioredoxin ...
Reactive oxygen species (ROS) trigger different morphogenic processes in filamentous fungi and have been shown to play a role in the regulation of the biosynthesis of some secondary metabolites. Some bZIP transcription factors, such as Yap1, AtfA and Atf
PIEZO1 expression was positively correlated with the YAP1 signature (CTGF, CYR61, and c-Myc, etc.) in primary samples. The secreted CTGF by cancer cells stimulated the CAF infiltration to form a stiffened collagen-enrichment microenvironment, thus activating PIEZO1 to form a po...
Indeed, ZEB1 was found to repress genes when in complex with PC2-CtBP-LSD1-LCoR or the SWI/SNF chromatin-remodelling protein BRG1, whereas formation of a ZEB1-Smad3-p300-P/CAF complex resulted in transcriptional activation6. Interestingly, Smad3 can also complex with YAP/TAZ-TEAD and ...