Yes‐associated protein (YAP) and its homologue TAZ are transducers of several biochemical and biomechanical signals, integrating multiplexed inputs from the microenvironment into higher level cellular functions such as proliferation, differentiation and migration. Emerging evidence suggests that Ca2+ is a ...
破坏这一过程会导致慢性损伤,包括离子失衡、Yki/Yap激活、细胞死亡和炎症细胞因子增加,使人联想到炎症性肠病。总之,保守的胆碱能通路促进上皮Ca2+电流愈合肠上皮。我们的发现证明了依赖神经和生物电的肠道再生,并推进了我们目前对组织在损伤后如何恢...
Overall, the results of the present study indicate that increased expression of Piezo1 is closely related to the occurrence and development of IVDD and that the Piezo1-mediated Ca2+/F-actin/Yap axis contributes to this process. Thus, targeting Piezo1 may provide a new strategy for the treatmen...
知了爱学 单选题 Ca2+发挥生物学效应需要 答案 有用 无用 B 进入题库
We showed previously that calcineurin leads to the Cln2 up-regulation by a mechanism that is mediated by the degradation of Yap1 (46). We showed that Sir3 was required for the elevation of the Cln2 level. In the regulation of the RLS, a functional link between Sir3 and Cln2 has not...
Deciphering the involvement of the Hippo pathway co-regulators, YAP/TAZ in invadopodia formation and matrix degradation Article Open access 25 April 2023 Msi1 promotes breast cancer metastasis by regulating invadopodia-mediated extracellular matrix degradation via the Timp3–Mmp9 pathway Article 21 ...
especially in KIRC.The extracellular matrix and PIEZO1 are key players in KIRC development.Matrix stiffness correlates with KIRC prognosis.Knockdown of PIEZO1 hinders KIRC cell growth and metastasis on stiff matrices.PIEZO1 activates the Ca2+/calpain/YAP pathway, contributing to KIRC progression on st...
AS Yap,EM Kovacs - 《Journal of Cell Biology》 被引量: 982发表: 2003年 Annexins and membrane dynamics Intracellular Ca2q signalling and Ca2q homeostasis are among the central problems in cell biology that have received major attention for a number of decade... Volker Gerke a,Stephen E Moss...
[60,61] but forced proliferation or maturation by inhibition/overexpression of cofactors, miRNA, molecules such as activated Yap (Yes-associated protein), cyclin B1-CDC2 complex, certain G1/S-phase molecules including CDK2, E2F1, cyclin D1 [62,63,64] may cause cardiac dysfunction. Therefore,...
人球蛋白G4(IgG4)酶联吸附测定试剂盒Pseudomonas taiwanensisYAP (D8H1X) XP® Rabbit mAb (PE Conjugate) 人膜辅蛋白(MCP/CD46)酶联吸附测定试剂盒 友好戈登氏菌TXNIP (D5F3E) Rabbit mAb 超微量ATP酶测试盒(Na+K+、Ca2+Mg2+-ATP酶)CTPS1 Antibody大肠埃希氏菌拉丁属名: Escherichia coli CTPS1 An...