另外YAP–TEAD复合体有三个结合界面（Interface 1,2,3）。利用多肽或者小分子与YAP直接竞争TEAD的结合，抑制YAP的活性就可以阻止YAP–TEAD复合物的形成比如多肽化合物Super-TDU，peptide 17和金黄三羧酸（aurintricarboxylic acid）阻断。图2 当前的治疗候选药物主要集中在间接抑制TEAD内部的口袋（比如VT3989）或者直接破...
研究成果发表在 The Journal of Cellular and Molecular Medicine 期刊题为“GPX4-mediated bone ferroptosis undermechanicalstress decreased bone formation via the YAP-TEAD signalling pathway”。 首先,HE 和 Masson 染色显示,在成骨细胞压力侧细胞形态收缩,死亡增加。对小鼠前成骨细胞 MC3T3 在体外施加压缩负荷(1...
研究成果发表在 The Journal of Cellular and Molecular Medicine 期刊题为“GPX4-mediated bone ferroptosis under mechanical stress decreased bone formation via the YAP-TEAD signalling pathway”。 首先,HE 和 Masson 染色显示,在成骨细胞压力侧细胞形态收缩,死亡增加。对小鼠前成骨细胞 MC3T3 在体外施加压缩负荷(...
研究成果发表在 The Journal of Cellular and Molecular Medicine 期刊题为“GPX4-mediated bone ferroptosis under mechanical stress decreased bone formation via the YAP-TEAD signalling pathway”。 首先,HE 和 Masson 染色显示,在成骨细胞压力侧细胞形态收缩,死亡增加。对小鼠前成骨细胞 MC3T3 在体外施加压缩负荷(...
1). The most important method of activating the RAS pathway in tumors is enhancement of EGFR, via gene amplification or transcription.91 Transcriptional enhanced associate domain (TEAD) Since its inception, TEAD has been best studied in the Hippo-YAP/TAZ signaling pathway and in tumorigenesis. ...
采用维替泊芬抑制YAP-TEAD的结合或通过AAVYap shRNA抑制小鼠肝脏YAP表达,可显著下调非诺贝特所致肝增大。其他因子如MYC、KRT23、RAS和RHOA也可能参与非诺贝特所促肝增大和肝再生。综上所述,非诺贝特可通过PPARα-YAP信号促进肝增大和肝再生,为非诺贝特作为一种潜在促进肝再生药物提供基础数据和参考依据。
Additionally, IL-17 treatment inducedto the activation of the NLRP3 inflammasomes and inhibition of the YAP/TEAD pathway in the H9C2 cells. Moreover, the IL-17-mediated effects on the H9C2 cells were alleviated by TAOK1 overexpression and augmented by TAOK1 knockdown. ...
Conclusion: TAOK1 played a crucial role in regulating IL-17-mediated increase in the pyroptosis and decrease in the proliferation of cardiomyocytes by regulating the activities of the NLRP3 inflammasomes and the YAP/TEAD pathway. 展开 关键词: YAP signaling proteins LABORATORY rats NLRP3 protein ...
为了进一步验证YAP对表皮角质形成细胞的积极作用,作者使用了YAP/TEAD相互作用抑制剂维替波芬(VP)。VP处理导致病变区域表皮明显增厚(图5F、5H)。通过PCNA免疫组化染色发现,表皮细胞增殖明显下调(图5G、5I)。综上所述,这些数据表明FGF10对...