Recent controversies about MDR and XDR-TB: Global implementation of the WHO shorter MDR-TB regimen and bedaquiline for all with MDR-TB?bedaquilineextensively drug-resistant tuberculosismultidrug-resistant tuberculosistreatmentTuberculosis (TB) is now the biggest infectious disease killer worldwide. Although...
Safety and effectiveness of all-oral and injectable-containing, bedaquiline-based long treatment regimen for pre-XDR tuberculosis in Vietnam.Nguyen TMP, Nguyen BH, Hoang TTT, Nguyen HA, Vu DH, Nguyen MH, Nguyen BN, De...
在高度耐药结核病患者中,全口服和含SLI的Bdq长程治疗方案的成功率相似。 Safety and effectiveness of all-oral and injectable-containing, bedaquiline-based long treatment regimen for pre-XDR tuberculosis in Vietnam. Nguyen TMP, Nguyen BH, Hoang TTT, Nguyen HA, Vu DH, Nguyen MH, Nguyen BN, Decroo...
21, 22 WHO has designed the DOTS-Plus which is an integral component of RNTCP to manage MDR-TB to be implemented through programme infrastructure in resource poor countries.23 The RNTCP under DOTS-PLUS is using a standardised treatment regimen (STR) for MDR/XDR-TB.24 3.2. Number of drugs...
MDR-TB Treatment: It's worse than we thought! The emergence of drug-resistant tuberculosis (TB) is a challenge to TB control in Europe.We evaluated secondline drug susceptibility testing in Mycobacterium tuberculosis isolates from patients with multidrugresistant, pre-extensively dr... CL Daley,CR...
Although use of Xpert MTB/RIF or Ultra as a front-line diagnostic reduced time to diagnosis and time to effective therapy, a retrospective analysis showed that treatment was suboptimal in approximately 49% of patients with drug-resistant tuberculosis given a regimen selected on the basis of ...
Cost-effectiveness of incorpor- ating bedaquiline into a treatment regimen for MDR/XDR-TB in Germany. Eur Respir J. 2015;46(6):1826-1829.Wolfson LJ, Gibbert J, Wirth D, Diel R. Cost-effectiveness of incorporating bedaquiline into a treatment regimen for multidrug-resistant/extensively drug-...
The successful treatment regimen for tuberculosis was the most important paradigm in tuberculosis (TB) history. From the difficult journey through cure by regal touch, cod liver oil surgical collapse therapy and sanatorium management, we advanced to successful short course chemotherapy in the hope to ...
treatmentTuberculosis (TB) is now the biggest infectious disease killer worldwide. Although the estimated incidence of TB has marginally declined over several years, it is out of control in some regions including in Africa. The advent of multidrug-resistant TB (MDR-TB) and extensively drug-...
Nano-engineering also allows for the co-delivery of multiple drugs within a single nanoparticle, crucial for the multi-drug regimen needed for XDR-TB. Encapsulating drugs within nanoparticles allows for controlled release at the infection site, maintaining effective drug levels over time and improving...