Here we show that the activity of the Wnt/β-catenin signaling pathway safeguards normal DNA methylation of mESCs. The activity of the pathway is progressively silenced during passages in culture and this results into a loss of the DNA methylation at many imprinting control regions (ICRs), loss...
Schematic diagram of the simplified phosphorylation-mediated regulation of the core Wnt/β-catenin pathway components.Phosphorylation of LRP6 at T1479 by CK1γ and at S1490 by GSK3 and Grk5/6 promotes Wnt signaling. Dvl phosphorylation mediated by RIPK4 and CK1ϵ is essential for Wnt signaling...
To test whether non-canonical Wnt signaling is required for ISC migration, we knocked down components of the pathway in ISCs, before infecting flies withEcc15. Infection-induced cellular protrusions, as well as ISC migration, were no longer observed after depleting Dsh, Otk, or the secondDrosoph...
To elucidate the mechanism of Wnt/β-catenin signaling pathway activation and inhibition, a schematic diagram was depicted in Fig. 1. Fig. 1 Schematic representation of activated and inhibited Wnt/β-catenin pathway. “WNT ON state”: Upon ligation of Wnts to their receptors composed of ...
Because Dsh is a branch point for several Wnt signaling pathways, we examined components downstream of Dsh to determine the pathway(s) controlling alignment of the ABar spindle. RNAi of jnk-1, a component of the JNK/planar cell polarity pathway, does not result in any defects in the ABar...
RNF43 starts to suppress Wnt signaling via Fzd degradation, but it also suppresses the p53 pathway simultaneously (upper left, diagram). Attenuated Wnt signal reduces RNF43 expression to release p53 suppression, then returns to the resting state. Stem cells can self-renew only in the small ...
Furthermore, LRP6-mediated Wnt signaling is downregulated in postmortem AD brains and negatively correlates with Aβ levels. Our findings define a critical role of LRP6-mediated Wnt signaling in synaptic integrity and establish that an impairment of this pathway contributes to AD pathogenesis....
Wnt1沉默树突状细胞趋化因⼦来诱导肺腺癌的适应性免疫耐受Wnt1 silences chemokine genes in dendriticcells and induces adaptive immune resistance in lung adenocarcinoma Dimitra Kerdidani 1,2, Panagiotis Chouvardas 1,3,4, Ares Rocanin Arjo5, Ioanna Giopanou 6,Giannoula Ntaliarda6, Yu Amanda Guo7,...
The Wnt signaling pathway is one of the key pathways in controlling cell proliferation, differentiation and morphogenesis. Breakdown of this pathway results in various disease states including tumorigenesis. The nucleotide sequences of the present invention encode a novel protein named Cristin1/R-spondin...
LncRNA HOTAIR is a prognostic biomarker for the proliferation and chemoresistance of colorectal cancer via MiR-203a-3p-mediated Wnt/ss-catenin signaling pathway. Cell Physiol Biochem. 2018;46(3):1275–85. Article CAS PubMed Google Scholar Jung Y-S, Park J-I. Wnt signaling in cancer: ...