As a result, all of them exhibited vigorous potency against HL60 cell line with IC50 values ranging from singe digital nanomolar to micromolar level. Besides, a majority of them displayed modest to good antiproliferative activities against the other four cell lines, including KB, SMMC-7721, HCT...
This dataset is quite challenging for the task of reproducing a ranking of binding affinities because all ligands are very strong binders, with IC50 values ranging from 0.04 μM to 21.39 μM. After performing a docking experiment with this dataset, reasonably good correlations between predicted ...
In a biochemical assay, GS-461203 inhibited the polymerase activity of the recombinant NS5B from HCV genotype 1b, 2a, 3a and 4a with IC50 values ranging from 0.7 to 2.6 micromolar. GS-461203 is neither an inhibitor of human DNA and RNA polymerases nor an inhibitor of mitochondrial RNA ...
All obtained products were evaluated as α-glucosidase inhibitors and exhibited excellent potency with IC50 values ranging from 15.2 ± 0.4 µM to 201.3 ± 4.2 µM. Among them, compound 3d was around 50-fold more potent than acarbose (IC50 = 750.0 ± 1.5 ...
Strand transfer biochemical assays using purified HIV-1 integrase and pre-processed substrate DNA resulted in IC50 values of 2.7 nM and 12.6 nM. Rilpivirine is a diarylpyrimidine NNRTI of HIV-1 and inhibits HIV-1 replication by non- competitive inhibition of HIV-1 reverse transcriptase (RT). ...
(A) Inhibitory concentration 50 values (IC50) for treatment with erlotinib, gefitinib, vandetanib or sorafenib in parental human lung adenocarcinoma CALU-3 cells (P) and in their TKI-R derivatives (ERL-R, GEF-R, VAN-R and SOR-R). Cell proliferation was measured with the MTT assay. The ...
IC50 values (by more than twofold) for LHRH-targeted NPs may be attributed to the affinity-based targeting of the LHRH ligand, which likely enhanced the accumulation of NCs within the cells [41]. According to the literature, higher cytotoxicity of NP-formulated drugs arises from NPs adsorbing ...
The results reported in Table 4 demonstrated that the prepared derivatives had less cytotoxic impact compared to 5-FU on the examined normal cells, with IC50 values ranging between 38.42 ± 1.23 μM and 122.99 ± 1.18 μM. The order of decreasing the biosafety effect correlates with the ...
In particular, whereas everolimus alone inhibited cell proliferation with IC50 values ranging between 0.1 and 1 mM (Figure 2A), sunitinib inhibited cell proliferation with IC50 values ranging between 1.5 and 2.5 mM (Figure 2B), as previously demonstrated (Damiano et al, 2013). To test the drugs...
MMAE toward the indicated tumor cells were determined by a MTS colorimetric method with 96-well plates as described. The IC50 values were presented as means (μg/mL) ±SD of the ADC as well as equivalent nM of MMAE concentration considering that the ADC has a stoichiometric ration of 3.5 M...