We determined the correlation of HS6ST2 with the IC50 values of over 750 anti-cancer medications. The data showed that increased HS6ST2 expression was correlated with reduced sensitivity to numerous drugs, indicating its probable participation in medication resistance; in contrast, increase HS6ST2 ...
In addition, the growth of Gram-positive bacteria (M. luteus and S. hominis) was efficiently inhibited by increasing concentrations of peptides 1-2, whereas the growth of Gram-negative bacteria was Table 1 | The IC50 values of peptides 1-3 toward Gram-positive/ Gram-negative bacteria ...
IC50 values of doxorubicin, Withaferin A, on treatment of A2780, A2780/CP70 and CAOV3 cells for 48 h with DOX and WFA, both alone or combination of DOX and WFA.Miranda Y. FongShunying JinMadhavi RaneRaj K. SinghR...
The novel dimers 1 and 2 exhibited inhibitory activities on soluble epoxide hydrolase (sEH) with IC50 values of 8.17 and 5.61 μM, respectively. Molecular dynamics studies illustrated that both 1 and 2 can occupy the catalytic pocket of sEH by forming stable hydrogen bonds with the key amino ...
BDS-I and BDS-II share the same binding site on brain synaptic membranes, with K0.5 values of 12 and 19 nM, respectively. We observed that BDS-I and BDS-II have some sequence homologies with other sea anemone Na+ channels toxins, such as AsI, AsII, and AxI. However, they had a ...
In vitro versus in vivo effects of triptolide: the role of transcriptional inhibition Results: In vitro, triptolide inhibited cellular transcription in A549 and THP-1 cells with IC50 values of 139 nM and 105 nM, respectively, similar... Christine,McCallum,Suzy,... - 《Therapy》 被引量: 12发...
In order to determine the optimal drug concentration in vitro, the IC50 values of TH302 with and without oxygen were 0.2 mg/mL and 0.1 mg/mL, respectively (Fig. 3C). The IC50 values of HPPH with and without laser irradiation were 0.025 mg/mL and 0.3 mg/mL, respectively (Fig. 3D). ...
1-adamantyl 2-methyl-2-(3-pyridyl)propanoate, 12, and 2-methyl-2-adamantyl 2-methyl-2-(3-pyridyl)propanoate, 14, which, while inhibiting the aromatase activity with IC50 values of 30, 35, and 40 microM, respectively, exhibited IC50 values toward hydroxylase/lyase of between 13 and 90 nM...
Allresvera- trolanditsderivativesreducedviabilityof HL-60 cellsina dose-dependent manner withtheirIC50 valuesof20-90µM. AscendingordersofIC50 val- ues were suffruticosol B, gnetin H,viniferin and resveratrolrespectively. HL-60 cellstreated with thefourstilbenesexhibitedthedistinct morpholo- gical...
Baseline features are shown in the top panel, while percentages of pathological regression are shown at the bottom. Dot lines indicate cutoff values of partial pathological response (PPR), PPR+, and major pathological response (MPR). b Overlap of partial response by radiological examination and ...