It seems reasonable to apply improved selection criteria that would allow one to differentiate patients with a relevant indication for thrombolytic therapy from those who do not have one. We present an overview of a diagnostic approach to acute stroke management that allows the clinician to ...
Current guidelines for the management of patients with acute ischemic stroke published by the American Heart Association Stroke Council include specific recommendations for the administration of intravenous recombinant tissue plasminogen activator (rtPA). Despite its effectiveness in improving neurological outcomes...
While waiting for the next breakthrough drug in acute stroke treatment, it is equally important to allocate considerable effort to find approaches to address the limitations of the only FDA-approved stroke therapy. 展开 关键词: Tissue plasminogen activator Hemorrhage Vasculature Blood-brain barrier ...
Such an approach can be used to select patients for thrombolytic therapy, monitor their outcome, and determine the clinical effectiveness of such an approach. These figures were provided by Steven Warach, MD, PhD, National Institute of Neurological Disorders and Stroke, Bethesda, Md, and ...
Sometimes, within a few hours of an ischemic stroke, intravenous heparin or TPA, or intra-arterial thrombolytics are administered to dissolve a blood clot or to prevent a blood clot from enlarging. Anticoagulants and antiplatelet agents can be used forpreventing recurrent strokein certain situations...
successfully treated up to nine hours after stroke onset, which is already much longer than the guidelines allow, Dr. Copen said. "Our findings suggest a need for a clinical trial to measure the effectiveness of thrombolytic therapy more than nine hours after the onset of an ischemic stroke."...
Expanding the window for thrombolytic therapy in acute stroke. The potential role of acute MRI for patient selection. BACKGROUND: Effective therapy was not available for treatment of acute stroke until 1995, when tissue plasminogen activator (tPA) was shown to improve neur... Albers,W G. - 《...
The Case Against the Present Guidelines for Stroke Thrombolysis: The Present Recommendations for Clinical Use Should Be Modified Thrombolytic agents offer great promise as therapeutic agents for selected patients with acute cerebrovascular symptoms. Preliminary data show that thrombolytic drugs, as a whole,...
Beijing tiantan hospital 16:00 Wang Yongjun: extended time window for thrombolytic therapy experience 翻译结果4复制译文编辑译文朗读译文返回顶部 16:00 am Beijing tiantan hospital Wang's army: Expansion of time windows intravenous thrombolytic experience ...
The existence of a therapeutic window for the restoration of blood flow is evident from experimental studies and clinical experience. It has formed the basis for the success of thrombolytic therapy (e.g. with alteplase) in ischaemic stroke if treatment is initiated within a short period (approxima...