acute stroke therapycerebral ischemia thrombolysisischemic stroketherapeutic windowIntravenous (i.v.) thrombolysis with tissue plasminogen activator (rt-PA, i.v. 0.9 mg/kg body weight) has been approved by European health authorities in 2002, with a 3-hr time window. The meta-analysis of i.v....
In many cases, these agents were designed to tackle events that are known to start almost immediately after onset of ischemia, which is far before a realistic therapeutic time window opens for most, if not all, patients with stroke. In other instances, they were evaluated beyond a realistic ...
The current data suggest that the time window for treatment with thrombolysis may extend out to 6 hours from stroke onset. How long is the time window for effective treatment? Does the time window vary with patient factors? If treatment is effective up to six hours from stroke onset, a much...
Restrictions to thrombolytic therapy for stroke-recommended only up to 4.5 h after onset and in those under 80 years of age-limit its use. Results from a recent trial support expansion of both the inclusion criteria and the time window for thrombolytic therapy, but further research is needed. ...
The window of opportunity for effective thrombolysis isfour and a half hours from the onset of the strokeand, in that time, a firm diagnosis of ischaemic stroke must be made. As a result, only about 1-11% of patients fulfil the criteria. ...
There was no limit with regard to time window for IVT. We excluded patients whose last known DOAC ingestion was more than 48 hours before stroke onset. No other exclusion criteria were applied, and centers were encouraged to provide records of consecutive patients over the study time frame. ...
Stroke thrombolysis is limited by the "last-seen well" principle, which defines stroke onset time. A significant minority of stroke patients (~15%) awake with their symptoms and are by definition ineligible for thrombolysis because they were "last-seen well" at the time they went to bed imply...
StrokeThrombolysisTissue plasminogen activator (tPA)Background:Current guidelines for ischemic stroke recommend initiating intravenous thrombolytic therapy within 4.5 hours after stroke onset or the last known well time. However, advancements in imaging techniques, such as CT perfusion and perfusion-diffusion...
Thus, we focused on the therapeutic time window for moderate hypothermia (30°C) in a transient focal ischemic model with 1 hour of CCA and distal ... H Zhao,G Steinberg - 《Stroke Res Treat》 被引量: 30发表: 2011年 Opening a New Time Window for Treatment of Stroke by Targeting HDAC...
Intravenous thrombolysis in an extended time window has been proposed in anterior circulation stroke based on the presence of a mismatch between the diffusion and perfusion lesions on magnetic resonance imaging (MRI).1A single report discussed this strategy in patients presenting beyond 4.5 hours with ...