While there is great potential for unbiased next-generation sequencing (NGS) approaches—eg, whole transcriptome sequencing (WTS)—for exploration, discovery, and clinical application in the realm of oncology, there are limitations that should be considered when relying on these methodologies for ...
We comprehensively analyzed the fusion transcript landscape in 572 acute myeloid leukemia (AML) and 630 myelodysplastic syndrome (MDS) patients by whole transcriptome sequencing (WTS). Totally, 274 fusion events (131 unique fusions) were identified in 210/572 AML patients (37%). In 16/630 MDS ...
Library prep and indexing primers for automation-compatible whole transcriptome sequencing of low-quality or low-input RNA samples. QuantityProductCatalog #Price xGen™ Broad-range RNA Library Prep 96rxn10009813$3,075.00 USD xGen™ Normalase™ Module 96rxn10009793$515.00 USD ...
Whole transcriptome signature for prognostic prediction (WTSPP): application of whole transcriptome signature for prognostic prediction in cancer Abstract Developing prognostic biomarkers for specific cancer types that accurately predict patient survival is increasingly important in clinical research and practice....
(proportion trend test;P = 3.4 × 10−6forZNF217and 3.3 × 10−4forSYPL1), suggesting an association with African ancestry. Whole-transcriptome data were available in a subset (n = 49) of Nigerian WGS samples. We examined the effect of non-coding mutations on ...
Whole transcriptome sequencing (WTS)doi:10.1002/9783527678679.dg14344This article has no abstract.American Cancer SocietyThe Dictionary of Genomics, Transcriptomics and Proteomics
Whole transcriptomesequencing (WTS) conducted in a subset of 85 patients was consistent with the results of WGS and standard cytogenomictechniques. This study validated the diagnostic use of WGS to uncover and characterize in detail the genetic aberrations in pediatricB-ALL. As a result, Ryan et...
tolerated and appeared to have a palbociclib dose-dependent durable clinical activity, with only one of 6 patients progressed at the optimal dose combination.We investigated the genes that mediate pG1 reprogramming by integrative whole exome sequencing (WES) and whole transcriptome sequencing (WTS). ...
Along this line of research, we performed whole-transcriptome sequencing (WTS) of blast cells from a paediatric AML patient with del(5q) to elucidate the mutational profile of this rare type of childhood leukaemia associated with resistance to chemotherapy and grim survival (Van den Berghe et al...
Whole transcriptome sequencingFusion transcript callingGene expression profilingConsidering the clinical and genetic characteristics, acute lymphoblastic leukemia (ALL) is a rather heterogeneous hematological neoplasm for which current standard diagnostics require various analyses encompassing morphology, ...