Whole Genome Sequencing Confirmed SARS-CoV-2 Reinfections Among Healthcare Workers in India with Increased Severity in the Second EpisodeSARS-CoV-2COVID-19ReinfectionsWhole Genome SequencingHealthcare workersBackground: Frontline healthcare workers (HCWs) are exceedingly exposed to SARS-CoV-2 and re...
The pairwise correlation among the seven RBC traits is shown in Table S2. WGS data and quality control in TOPMed WGS was performed as part of the NHLBI TOPMed program. The WGS was performed at an average depth of 38 × by six sequencing centers (Broad Genomics, Northwest Genome Institute,...
Another human genome sequence was recently determined using one of these approaches7. However, much bigger improvements are necessary to enable routine whole human genome sequencing in genetic research. We describe a massively parallel synthetic sequencing approach that transforms our ability to use DNA ...
Table 1 Statistics of sequencing and assembly Full size table Transposable elements (TEs) can constitute a large portion of a eukaryotic genome; for example, the human genome is 45% TEs23. The genome of the tongue sole, however, is only 5.85% TEs (Supplementary Tables 6 and 7 and Supplemen...
Due to the multiplicity of drugs used in the treatment of TB, determining the full resistance profile for a patient suspected of having drug-resistant disease requires the examination of many loci. Next-generation whole genome sequencing offers an attractive option as it simultaneously examines all ...
A new strain, namely FC II, surpassed all other filamentous cyanobacteria in terms of survival in 500 m2 raceway ponds at our pilot facility. Here, we report the whole-genome sequencing of the filamentous cyanobacterial strain FC II and have provided assembly, annotation, and insights on ...
Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma. Genome Res. 23, 1422–1433 (2013). CAS PubMed PubMed Central Google Scholar Xue, R. et al. Variable intra-tumor genomic heterogeneity of multiple lesions in patients with hepatocellular carcinoma. Gastroenterology 150...
Recent advances in whole-genome sequencing have brought the vision of personal genomics and genomic medicine closer to reality. However, current methods lack clinical accuracy and the ability to describe the context (haplotypes) in which genome variants co-occur in a cost-effective manner. Here we...
GCAT genesT A C G GCAT Review The Present and Future of Whole Genome Sequencing (WGS) and Whole Metagenome Sequencing (WMS) for Surveillance of Antimicrobial Resistant Microorganisms and Antimicrobial Resistance Genes across the Food Chain Elena A. Oniciuc 1,†, Eleni L...
Whole-genome sequencing is an important tool for understanding microbial evolution and identifying the emergence of functionally important variants over the course of epidemics. In October 2010, a severe cholera epidemic began in Haiti, with additional cases identified in the neighboring Dominican Republic...