NIH researchers complete whole-exome sequencing of skin cancere Science News
A growing number of druggable targets and national initiatives for precision oncology necessitate broad genomic profiling for many cancer patients. Whole exome sequencing (WES) offers unbiased analysis of the entire coding sequence, segmentation-based de
Whole-exome sequencing reveals recurrent somatic mutation networks in cancer. Cancer Lett. 2013;340(2):270-6.XiaopingLiu, JiguangWang, LuonanChen. (2013) Whole-exome sequencing reveals recurrent somatic mutation networks in cancer. Cancer Letters 340 , 270-276 /...
In a series of case studies, Nishihara and his colleagues have already shown PleSSision-Exome’s potential. One middle-aged woman with breast cancer, for example, had no actionable DNA alterations, as gauged by a standard gene panel test. But a mutation found by full exome sequencing reveale...
the RNA-seq data are often notdetected in the WES data and vice versa. A subsampling study of the prostate datasuggests that a coverage of at least 75x is necessary to achieve high accuracy.Keywords: fusion gene, acute myeloid leukemia, whole exome sequencing, prostate cancer, discordant ...
We screened 703 single-nucleotide polymorphisms (SNPs) of the endo-lysosomal ion transporter genes in the Saudi population and identified cancer-associated variants that have been reported in other populations. Methods Utilizing previously derived local data of Whole-Exome Sequencing (WES), we examined...
Whole exome sequencing Tomorrow’s cancer research breakthroughs are on the horizon. xGen™ NGS for whole exome sequencing includes offerings for both routine and difficult samples—designed to minimize efforts while maintaining key data metrics and positioning your research for limitless potential. ...
Longitudinal whole exome sequencing of cell-free DNA in advanced bladder cancer. mutation profiles.Conclusions:Longitudinal WES of cfDNA is feasible in a subset of advanced bladder cancer patients with sufficiently high tumor purity in the... A Ravi,I Epstein,D Freeman,... - 《Journal of Clinic...
Whole genome sequencing (WGS) is becoming the preferred method for molecular genetic diagnosis of rare and unknown diseases and for identification of actionable cancer drivers. Compared to other molecular genetic methods, WGS captures most genomic variation and eliminates the need for sequential genetic ...
815 Whole Exome Sequencing Identifies Potential Therapeutic Targets for Castration Resistant Prostate Cancer - European Journal of Cancerdoi:10.1016/S0959-8049(12)71448-XR. MenonM. DengD. BoehmF. FendS. PernerElsevier LtdEuropean Journal of Cancer...