根据更新2024年世卫组织发布的细菌优先病原体清单(Bacterial Pathogen Priority List,BPPL),本文首先评估了目前抗菌药物研发、生产系统在多大程度上解决了重要耐药细菌病原体(drug-resistant bacterial priority pathogens, BPPs)引起的感染,并以此回顾了当前的研发情况,同时引导后续的研发应面向最迫切但尚未满足的医疗需求。
但这并不意味这些病原真菌不重要。相反,《清单》明确指出,在某一个具体国家或者地区,当地卫生系统需要在《清单》的基础上,高度重视当地病原真菌感染的实际情况。 请点击以下“阅读原文”获取who fungal priority pathogens list to guide research, development and public healt...
根据更新2024年世卫组织发布的细菌优先病原体清单(Bacterial Pathogen Priority List,BPPL),本文首先评估了目前抗菌药物研发、生产系统在多大程度上解决了重要耐药细菌病原体(drug-resistant bacterial priority pathogens, BPPs)引起的感染,并以此回顾了当前的研发情况,同时引导后续的研发应面向最迫切但尚未满足的医疗需求。
在《清单》里,共纳入了19种(类)病原真菌,基本涵盖了影响较大的强致病性真菌和特殊耐药真菌。依据重要程度,《清单》将这些真菌,划分了三个等级,分别为:关键优先级(Critical Priority Group)、高级优先级(High Priority Group)和中级优先级(Medium Priority Group)。等级评定主要依据致死率、感染率、诊疗难度等相关因素...
WHO fungal priority pathogens list to guide research, development and public health action. WHO https://www.who.int/publications/i/item/9789240060241 (2022). Rajasingham, R. et al. Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis. Lancet Infect. Dis. 17,...
important pathogensOPP other priority pathogens on the WHO bacterial priority pathogens list(“high”and“medium”priority)OUCRU Oxford University Clinical Research UnitOXA oxacillinasePA Pseudomonas aeruginosaPBP penicillin-binding proteinxiv2023 Antibacterial agents in clinical and preclinical develo 74、pment...
WHO revised bacterial priority pathogens list to encourage global actions to combat AMRdoi:10.1016/j.hlife.2024.10.003Yingying MaPan ChenYin MoYonghong XiaohLife
resistantinfections.Immediateglobal•2023Antibacterialagentsinclinicalandpreclinical coordinationandcooperationisessentialdevelopment:anoverviewandanalysis.Geneva:World HealthOrganization;2024. toenhanceinnovativeRD,improveAMR •WHOBacterialPriorityPathogensList,2024:bacterial ...
[1] WHO fungal priority pathogens list to guide research, development, and public health action [2] Fernández-Cruz A, Semiglia MA, Guinea J, et al. A retrospective cohort of invasive fusariosis in the era of antimould prophylaxis. Med Mycol. 2020;58(3):300-309. ...
pathogens of increasing concern. On 25 October 2022, the WHO released its first list of 19 fungal priority pathogens, identified as having the greatest threat to public health [5,6]. The WHO Fungal Priority Pathogens List represents the first global response to identify and prioritize fungal ...