2024年5月17日世界卫生组织发布了最新的“细菌重点病原体清单”(WHO bacterial pathogen priority list,WHO BPPL),这份名单包含了15类抗菌药物耐药(antibiotic resistant,ABR)病原体。2024年WHO BPPL在2017年版本的基础上,更新并完善了抗菌药物耐药性病原体的优先顺序,将其分为严重级别组、高级别组和中级别组三个...
根据更新2024年世卫组织发布的细菌优先病原体清单(Bacterial Pathogen Priority List,BPPL),本文首先评估了目前抗菌药物研发、生产系统在多大程度上解决了重要耐药细菌病原体(drug-resistant bacterial priority pathogens, BPPs)引起的感染,并以此回顾了当前的研发情况,同时引导后续的研发应面向最迫切但尚未满足的医疗需求。
根据更新2024年世卫组织发布的细菌优先病原体清单(Bacterial Pathogen Priority List,BPPL),本文首先评估了目前抗菌药物研发、生产系统在多大程度上解决了重要耐药细菌病原体(drug-resistant bacterial priority pathogens, BPPs)引起的感染,并以此回顾了当前的研发情况,同时引导后续的研发应面向最迫切但尚未满足的医疗需求。
[2]Chiurlo M, Mastrangelo A, Ripa M, Scarpellini P. Invasive fungal infections in patients with COVID-19: a review on pathogenesis, epidemiology, clinical features, treatment, and outcomes. New Microbiol. 2021;44(2):71...
[3] WHO fungal priority pathogens list to guide research, development, and public health action [4] Bongomin F, Gago S, Oladele RO, Denning DW. Global and Multi-National Prevalence of Fungal Diseases-Estimate Precision. J Fungi (Basel). 2017;3(4):57. Published 2017 Oct 18. ...
Some new fungal species are believed to have emerged due to climate change. For example,Candida auris, which is in the WHO critical priority group, is a new fungal pathogen that has emerged since 2009 and has now spread globally, with reports of infections from every continent [14].Candida ...
•WHOBacterialPriorityPathogensList,2024:bacterial datacollectionandsharing,andimplement pathogensofpublichealthimportancetoguide investmentstrategiesthatarefocusedonresearch,developmentandstrategiestopreventand addressingtheneedsofvulnerablepatients,controlantimicrobialresistance.Geneva:WorldHealth ...
[3]WHO fungal priority pathogens list to guide research, development, and public health action [4]Bongomin F, Gago S, Oladele RO, Denning DW. Global and Multi-National Prevalence of Fungal Diseases-Estimate Precision. J Fungi (Basel). 2017;3(4):57. Published 2017 Oct 18. ...
The World Health Organization (WHO) has released a fungal priority pathogen list (FPPL) to prioritize fungal pathogens based on their research and development needs and public health importance. The list categorizes 19 major invasive fungal pathogens into critical, high, and medium prio...
(direct-acting small molecules)and non-traditional antibacterial agents in development worldwide.The report evaluates to what extent the present pipeline addresses infections caused by drug-resistant bacteri 81、al priority pathogens(BPPs)according to the updated 2024 WHO bacterial priority pathogen list...