While white matter disease has been associated with strokes, cognitive loss, and dementia, it also has some physical and emotional symptoms such as balance problems, falls, depression, and difficulty multitasking (e.g., walking and talking). Understanding Migraine-Related Brain Lesions on Your MRI ...
Clinically, patients with white matter disease have a variety of symptoms, and diagnosis in this group of illnesses must be based on a combination of neurological findings, blood tests, and neuroimaging tests. Radiation to the brain during treatment of primary and metastatic brain tumors can cause...
Here we found increased brain activity in the bilateral anterior thalamic radiation in major psychiatric disorder patients when compared with healthy controls. The spatial pattern of white matter dysfunction in patients with major psychiatric disorders was correlated with the distributions of disease-related...
White matter hyperintensities (WMHs) are commonly seen on brain MRI in older people, and result from chronic ischaemia associated with cerebral small vessel disease The histopathology of WMHs is heterogeneous, with tissue damage ranging from slight disentanglement of the matrix to varying degrees of my...
a focus on myelin and oligodendrocytes Sara E. Nasrabady1*, Batool Rizvi4, James E. Goldman2,4 and Adam M. Brickman3,4 Open Access Abstract Alzheimer's disease (AD) is conceptualized as a progressive consequence of two hallmark pathological changes in grey matter: extracellular amyloid plaques...
BackgroundClinical depression is associated with reductions in white-matter integrity in several long tracts of the brain. The extent to which these findings are localized or related to depressive symptoms or personality traits linked to disease risk remains unclear.MethodMembers of the Lothian Birth ...
White matter lesions have been related to affective disorders and a history of late-onset depression in psychiatric patients. Their relation with mood disturbances in the general population is not known. We investigated the relation between white matter lesions and the presence of depressive symptoms ...
disease (Fig. 20.3). In still younger patients, many genetic disorders, referred to as leukodystrophies, affect predominantly the white matter (Fig. 29.1). Abscesses often originate at the gray–white junction, but extend into the white matter (Fig. 18.8). All of the most frequent intra-...
To identify the most important parameters associated with cerebral white matter hyperintensities (WMH), in consideration of potential collinearity, we used a data-driven machine-learning approach. We analysed two independent cohorts (KORA and SHIP). WMH volumes were derived from cMRI-images (FLAIR)....
The diagnosis of the CH was based on the criteria of the International Headache Society [1]. Clinical parameters such as disease duration and attack frequency were acquired for all patients. MRI scans were acquired in the interictal period. None of the subjects had white matter lesion on the ...