Myelin, the electrically insulating sheath on axons, undergoes dynamic changes over time. However, it is composed of proteins with long lifetimes. This raises the question how such a stable structure is renewed. Here, we study the integrity of myelinated tracts after experimentally preventing the ...
Oxidative stress results from an imbalance between reactive oxygen/nitrogen species and antioxidants, resulting in macromolecular damage. Indeed, the brain is particularly vulnerable to oxidative stress given its high oxygen consumption and high content of oxidizable polyunsaturated fatty acids. Convergent e...