gradually revealed that during ontogeny, primitive macrophage populations derived from the embryonic yolk sac or fetal liver spread into entire peripheral tissues, colonize, and maintain themselves in tissues by self-renewal. These populations are the sources of some tissue-resident macrophages in adulthoo...
gradually revealed that during ontogeny, primitive macrophage populations derived from the embryonic yolk sac or fetal liver spread into entire peripheral tissues, colonize, and maintain themselves in tissues by self-renewal. These populations are the sources of some tissue-resident macrophages in adulthoo...
Despite the resurgences in positive cases after reopening businesses in May, the country is seeing a shift in mindset surrounding the pandemic as people have been eagerly trickling out from federally-mandated quarantine into restaurants, bars, and gyms across America. History can teach us about the...
experiments suggests that intranerve injections limits the transduction of axons. This biodistribution pattern is unusually limited for an AAV2/9-based gene therapy treatment. Indeed, different delivery routes of AAV2/9 in mammals (mouse, rat, dog and NHP), such as intravascular, intracerebroventri...
High SM levels are found in the central nervous system of mammals, particularly in the myelin sheath surrounding neuronal axons [55]. The functions of SMs includes regulation of immune responses, signal transduction, axonal maturation and possibly brain development [37]. Furthermore, SM and CER (...
Cell motility and invasion take advantage of the localised generation of ATP by mitochondria to turnover of focal adhesions (FAs; a key component in cell motility) and actin cytoskeleton reorganisation (Fig.3, centre panel). Neuronal axons served as a useful model for some of the first mitochon...
Shh (and Smo) mutations in zebrafish models resulted in abnormal optic nerve growth, and some axons even failed to exit the eye [21]. Furthermore, continued signaling is needed for the maturation of the optic cup, and the inactivation of Shh at this stage leads to a hypoplastic optic ...
This should be seen in the general terms of the acute spinal cord injury, as the traumatic primary injury as the epicenter of the lesion triggers all pathological sequele, and comprises cell death, local severance of axons, and damage to blood vessels with the focal hemorrhage around the ...
White matter is white because those axons are usually wrapped in myelin sheath, which is fatty white tissue. There are two main regions of gray matter in the brain—the internal cluster of limbic system and brain stem parts we discussed above, and the nickel-thick layer of cortex around the...
so the samples used were myelinized axons. These analyses showed an alternation of protein and lipid layers in support of the paucimolecular model [116]-[118]. Unfortunately, we know now that this biological material is physiologically very specific and can hardly be compared to a regular cell...