However, it is clear that with a greater number of molecules with a well-established mechanism of action available, more effective development of real drugs through modern methods of bioinformatics and drug design can be realized. Additionally, from this point of view, these compounds are of ...
Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy * Authors to whom correspondence should be addressed. Molecules2022,27(15), 5011;https://doi.org/10.3390/molecules27155011 Submission received: 20 July 2022/Revised: 28 July 2022/Acce...
Dry material which can be hydrated into an aqueous gel comprising (1) a matrix comprising a macromolecular substance A, capable of forming a porous aqueous gel when it is in the presence of water, (2) a water-soluble linear polymer B, (3) a plasticizer for the macromolecular substance A ...
Recently, chemists have begun to develop small molecule systems that fold in a similar way and these may help to answer more complex questions or find applications in artificial molecular assemblies. Study of the properties of a family of oligoamides composed of alternating repeats of isophthalic ...
They are more efficacious, selective and specific than small molecules, and their products of degradation are amino acids, which present a reduced risk of drug-drug interactions. Additionally, their short half-life means a lower propensity for accumulation in tissues4. Their immediate response and ...
dibenzoic esters of glycols, hydroxybenzoic esters, esters of saturated monocarboxylic acids, esters of saturated dicarboxylic acids other than compounds (I), esters of unsaturated dicarboxylic acids other than compounds (I), amides and esters of aromatic sulfonic acids, alkylsulfonic esters, glycerol ...
Group differences in fractional anisotropy (FA; movement of liquid molecules across the WM) and mean diffusivity (MD; typical movement of water particles) had been analyzed as indices of WM integrity making use of FreeSurfer and FMRIB Software Library (FSL) processing channels. Lower FA and ...
Typically amides are prepared in non-equilibrium processes e.g. by activation of carboxylic acids through conversion to acid chlorides followed by reaction with amines, or continuous removal of the condensate throughout the reaction in order to drive it to completion. Both of these methods ...
are conflicting as regards the donor atomset.2 Only one recent structural report makes the co-ordination of dithiomalonamides, toward selected covalentmetal halides, less ambiguou~.~As a contribution towards clarifying the co-ordinative be-haviour of these ligands toward transition-metal ions and...
In certain instances, it is possible to have two separate nucleophilic groups on said aromatic ring, each of which has an ortho substituent as described above; a highly efficient compound is provided since oxidation of the nucleophilic groups can prevent the release of two molecules of a ...