To identify molecular targets in leukemia stem cells (LSCs), this study compared the protein expression profile of freshly isolated CD34+/CD38 cells with that of CD34+/CD38+ counterparts from individuals with acute myelogenous leukemia (n = 2, AML) using isobaric tags for relative and absolute ...
TRAIL-R3 expression was also high on CD34+/CD38− cells, the compartment that harbors the leukemia initiating stem cell. Expression levels of pro-apoptotic TRAIL receptors were not correlated to the susceptibility for soluble TRAIL, which was generally low (mean level of cell death induction 14...
Tolusso B, De Santis M, Bosello S, Gremese E, Gobessi S, Cuoghi I, Totaro MC, Bigotti G, Rumi C, Efremov DG, Ferraccioli G (2009) Synovial B cells of rheumatoid arthritis express ZAP-70 which increases the survival and correlates with the inflammatory and autoimmune phenotype. Clin ...
The present inventors intensively studied to discover that SP cells exist in human amniotic mesenchymal cell (hereinafter also referred to as “HAMC”) layer and in human amniotic epithelial cell (hereinafter also referred to as “HAEC”) layer, and that the SP cells express some markers of stem...