Naïve cells are non-active lymphocytes that recognize and bind to specific antigens, become activated, and launch target attacks against foreign pathogens.
To address this question we have developed an in vitro model in which purified WC1 γ/δ T cells (CD2~-, CD3~+, CD8~-) from naive animals proliferate in response to irradiated autologous Theileria annulata-infected monocytes together with IL-2. This response was not MHC restricted and ...
the exact mechanism of function of these cells in the pathogenesis of IBD is not yet clear and needs to be further studied. Increased ILC2 cell populations have also been reported in inflamed tissues of patients with newly diagnosed
Intestinal dendritic cells (DC) and macrophages play a key role for the maintenance of intestinal integrity by initiating innate and adaptive immune responses. Although DC and macrophages have been viewed as distinct lineages, the reliability of surface markers for the definition of DC and macrophages...
Recent years have seen so-called natural killer T (NKT) cells emerge as important regulators of the immune response. The existence of NKT-cell subsets, and other types of T cell that resemble NKT cells, is an ongoing source of confusion in the literature
Zap-70, a crucial molecule for the selective activation of T cells, through its interaction with the chain of the TCR/CD3 complex, is a tyrosine kinase. This well studied molecule has gained a renewed interest upon the demonstration of its transduction and expression in B cells from patients ...
Several diseases or disease sub-types may look alike or appear to have similar size cells under a microscope but have different behaviors and different treatments. One way to differentiate them is to detect specific molecules on these cells that act as markers. ...
However, such therapeutics may have important toxicity on the long term. Based on proof of concept in mice [46•] and demonstration of the hyper activation of the mTOR pathway in ALPS-FAS T cells [47•], References and recommended reading Papers of particular interest, published within the...
More recently, selective immune suppression has been tried. Phase II trials showed promising efficacy, but Phase III studies have been disappointing. 展开 关键词: anti-CD3 auto-antigens C-peptide GAD immune intervention Type 1 diabetes DOI: http://dx.doi.org/10.1586/erv.11.194 年份: 2014 ...
cells can present with phenotypic features of any of the major naïve or memory T cell subsets (based on the differential expression of CD62L [L-selectin] and CD45RA) but commonly overexpresses CCR4 and programmed cell death protein 1 (PD1), which suggests that malignant cells have a ...