Hybrid green fluorescent protein (GFP) which binds, measures and detects calcium using fluorescent/chemiluminescence resonance energy transfer (F/CRET)doi:US6936475 B2A modified bioluminescent system comprising a fluorescent molecule covalently linked with a photoprotein, wherein said link between the two...
在钙离子存在时,穿孔蛋白结合到靶细胞膜上并聚合形成环形跨膜通道,其结果增加细胞的通透性,并导致细胞死亡。 初译:In the presence of calcium ions, perforin binds to the target cell membrane and polymerizes to form a circular transmembrane channel, which results in increased cell permeability and cell ...
The action of large conductance, calcium-activated, and voltage-dependent potassium (BK) channels was further curtailed by the presence of PG e-cig aerosols. Newly discovered in this study, PG can be metabolized to methylglyoxal (MGO) in airway epithelia. PG e-cig aerosols exhibited elevated ...
Finally, an additive effect was observed for the combination of Ur-A/C with the androgen receptor (AR) inhibitor enzalutamide. This anti-androgen drug binds to the AR thus blocking binding of this receptor to testosterone and dihydrotestosterone49,52. Thus, enzalutamide inhibits the AR-signaling ...
US5981712 1997年7月25日 1999年11月9日 The United States Of America As Represented By The Department Of Health And Human Services Antibody which binds to carboxyamido-triazole resistance protein; for detecting resistance to drug which prevents calcium influx in biological samples/cells...
One aspect of the present invention relates to a method of treating hot flashes in a patient which is carried out by providing a compound which binds a α 2 δ subunit of a voltage-gated calcium channel and administering the compound to a patient experiencing hot flashes under conditions ...