The experiment recorded here, therefore, was projected to determine whether or not calcium ions could actually bind to phospholipids and if so, whether the binding of calcium ions would be affected by monovalent cations or other substances.
The two calcium sites of parvalbumin were found to be strongly cooperative in binding Ca 2+ ion. Up to four calcium ions were found to bind to calmodulin at high calcium concentration levels. Strong cooperativity was detected between the third and fourth Ca 2+ binding sites of calmodulin (...
In 1883, Ringer showed that to get isolated hearts to contract, it was necessary to have Ca2+ ions in the perfusion medium [421]. This was the first demonstration of the critical role of calcium in cellular activity. Remarkably, a hundred years passed before the importance of calcium was re...
where ICa and IM are the currents due to calcium ions and due to all monovalent ions, respectively; \({[{{{\rm{Ca}}}^{2+}]}_{{{\rm{o}}}\) is the extracellular calcium concentration; [M] is the concentration of monovalent ions, assumed to be identical inside and outside the cel...
In one of them calcium ions accumulate at the interior surface of the post-synaptic membrane and bind to the cholinergic receptors, thereby causing desensitisation by producing or sustaining some inactive receptor conformation 6 . We tested the model for desensitisation which involves internal calcium...
Calcium alginate is incompatible with alkalis and alkali salts. Propranolol hydrochloride has been shown to bind to alginate molecules, suggesting that propranolol and calcium ions share common binding sites in the alginate chains; the formation of the calcium alginate gel structure was impeded in the...
(Gulmann et al., 2002; Nonaka et al., 2008). Through its ability to bind Ca2+ions,phospholipids,inositol polyphosphatesor other proteins, the protein kinase C mediates a wide range of intracellular processes, e.g. the PI3K/IP3/PKC signalling pathway, secretion, cell growth and differentiation...
Ionic structure of phospholipid membranes, and binding of calcium ionsIonic structure of phospholipid membranes, and binding of calcium ionsdoi:10.1016/0005-2736(73)90073-4Radiotracer measurements of adsorption showed that the binding of Ca2+ with the phosphate groups of phosphatidylserine, phosphatidylet...
Its molecular structure consists of blocks of (1-4)-linked β-D-mannuronate (M) and α-L-guluronate (G) residues, which are responsible for its ability to form gel in the presence of calcium ions. This property is central to its functionality, as the divalent calcium ions create junction...
While the concentration of hydrogen ions (the acidity) remains low because of the buffering effect of the food, the release of gastrin continues. As digestion proceeds and the stomach begins to empty, however, the acidity increases because of the diminishing neutralizing effect of the food. When...