Nicastrin modulates presenilin-mediated notch/glp-1 and βAPP processing. Nature 407, 48–54 (2000).Describes the discovery of a protein that is a component of the presenilin complex. CAS PubMed Google Scholar Saura, C. A. et al. The nonconserved hydrophilic loop domain of presenilin (PS...
GLP-1 is secreted after meals from the distal ileum, proximal colon, and the vagal nucleus of the solitary tract, and it has multiple effects as an incretin hormone [32]. Its main role is to regulate blood glucose by inhibiting glucagon secretion and enhancing insulin secretion from the pancr...