From a clinically ill cow, aged between two and three years, exhibiting lethargy, the Kaptombes virus (KPTV) was first isolated. Following the initial detection, three more cows in neighboring locations were discovered to be infected the subsequent year. A 10% prevalence of neutralizing antibodies...
VHL disease is recognised as a hereditary cancer syndrome predisposing to the development of highly vascularised multiple endocrine tumours. More than 20–25% of these patients develop pheochromocytoma, frequently multifocal and bilateral, with a risk of malignancy super-imposable to those of MEN 2A ...
Furthermore, we have discovered that in this OMV-associated form, the toxin is trafficked to host cells by a cholesterol- and receptor-independent mechanism in contrast to the mechanism by which free LtxA is delivered. Because OMV-associated toxin is trafficked to host cells in an entirely ...