VHL AcronymDefinition VHLVon Hippel-Lindau(disease) VHLVery High Level Language VHLVirtual Health Library(online information resource; Latin-American and Caribbean Center on Health Sciences Information) VHLvon Hippel-Lindau gene VHLVista Higher Learning, Inc.(language program publisher; Boston, MA) ...
autism is frequently associated with anxiety, stemming from feelings of social isolation, which can, in turn, elevate the risk of depression in some cases [19]. In addressing these concerns, engaging in sports activities can yield significant benefits, as ...
Currently, the patient is asymptomatic and presents sustained stable disease, despite the presence of lung, para-aortic lymph nodes and femoral metastases. Adequate response to treatment with control of tumor progression, absence of significant cardiovascular events and other neoplasms, and lack of ...
Adipocyte-specificVhlKO mice using aP2 and Fabp4 dual promoters, whereby HIF-1α, HIF-2α, and HIF-3α are constitutively upregulated in the affected adipocytes, demonstrate no reduction in body weight gain, although visceral fat mass is significantly decreased25(Table1). These mice have a p...
doi:10.2147/itt.s49923Dove PressImmunoTargets and Therapy
Chikungunya (CHIK) is a viral disease transmitted by mosquitoes. The first cases in Brazil were confirmed in 2014. Between 2016 and 2017, over 300,000 cases were identified during this period, with nearly 300 deaths. The clinical manifestations, pathogenesis and risk factors for occurrence of sev...
Cachexia is typically associated with a number of underlying chronic degenerative diseases, such as cancer, chronic obstructive pulmonary disease (COPD), HIV, chronic heart failure, diabetes, liver failure, rheumatoid arthritis, and chronic kidney failure [1]. Here, we will chiefl...
Although the expression of PKC isozymes is altered in multiple cancer types, the causal relationship between such changes and the initiation and progression of the disease remains poorly defined. Animal models developed in the last years helped to better understand the involvement of individual PKCs ...
Understanding the invasion mechanisms is thus critical to devise new therapeutic strategies. Therefore, the creation of in vitro models that enable these mechanisms to be studied represents a crucial step. Since in vitro models represent an over-simplification of the in vivo system, in these years ...
Similar to VHL disease, tumors associated with SDHx, HIF2A, and FH mutations produce and/or secrete noradrenaline/normetanephrine but rarely adrenaline/metanephrine [16, 27, 50]. Lack of staining for SDHB in PHEO is highly suggestive of germline mutations in SDHx genes (90.0%), whereas im...