mitosismitotic spindleIn most tumor cells a chromosomal instability leads to an abnormal chromosome number (aneuploidy). The mitotic checkpoint is essential for ensuring accurate chromosome segregation by allowing mitotic delay in response to a spindle defect. This checkpoint delays the onset of anaphase...
Activation of this signalling cascade has been shown to drive entry into G1 but there are also a number of reports, which suggest members of this pathway are required for normal G2/M progression and entry into mitosis (Wright et al, 1999; Hayne et al, 2000). Activation of the ERK ...
Pim and human securin can block only sister chro- mosome separation and not later mitotic events, even when stable forms of the protein are overexpressed [18,22], making these poor choices for mediators of checkpoint arrest -- if cells relied on these proteins, they would exit mitosis without...