Moreover, treatment for T1D is not completely physiological. Normally, insulin is secreted from the pancreas into the portal vein and subsequently reaches the liver, where it is mostly metabolised. Conversely, during T1D treatment, insulin is absorbed from the subcutaneous tissue to the peripheral ...
Molecular mechanisms and physiological roles of Atg5/Atg7-independent alternative autophagy. Proc Jpn Acad Ser B Phys Biol Sci. 2017;93:378–85. Article CAS PubMed PubMed Central Google Scholar Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, et al. Molecular mechanisms...
However, ICIs can interfere with the physiological function of immune checkpoints to promote self-tolerance, thereby inducing a unique spectrum of immune-related adverse events. Various endocrinopathies have been reported, including new-onset diabetes that may, at least partly, resemble autoimmune type...
Cognitive challenges in children after a viral infection are multifaceted, encompassing direct physiological effects and indirect psychological, behavioral, and social factors, requiring specifically tailored interventions for this population. The frequent manifestation of neurocognitive symptoms in children after ...
Aggresomes refer to an assemblage of aggregated or misfolded proteins that occur when the cell’s degradation system is overwhelmed. Takashaki et al. found that USP10 inhibits ubiquitinated protein-induced apoptosis by inducing aggresome formation; USP10 interacted with p62 and this interaction ...
various physiological processes, such as increased cell survival, angiogenesis and suppression of anti-tumour adaptive immune responses are regulated by leucocyte infiltrates67. Moreover, the transcription factor NF-κB, a key mediator of inflammatory responses, regulates the expression of genes involved ...
Sphingolipids and their analogous molecules are potent modulators of immune mechanisms, cell fate [20] and physiological responses [21]. In the last decade, their usage as therapeutic compounds constantly gained interest. Sphingolipids were hypothesized as potential therapeutic compounds in the context ...
For both invertebrates and vertebrates, survival of prolonged periods of anoxia is a remarkable physiological feat, nevertheless, most of this work has focused on extended anoxia tolerance and not on hormesis. While these animals may gain survival, longevity, and/or higher reproductive outputs from ...
(Heineke et al.2005), again underlining MLP’s role in hypertrophic signalling cascades. Moreover, MLP protein levels have been shown to increase during stress such as aortic banding in wild-type mice (Kuhn et al.2012). However, overexpression of MLP does not confer any protection to the ...
may lead to the desynchronization of multiple physiological processes and the disruption of normal homeostasis in tissues16, and, with that, an increase in inflammatory activity17, disturbance in the activity of the neuroendocrine stress system18,19, reduction of immunological defenses19and excessive for...