Roughly ten years ago the FDA approved most of the presently used anti-VEGF drugs for the treatment of neovascular AMD and other eye pathologies characterized by ocular neoangiogenesis. However, the recent findings on the physiologic activities of VEGF isoforms impose to reconsider the inhibitory effe...
2.4. Mechanisms of strand separation: do helicases play an active or passive role? As the translocation of a helicase strictly occurs along a single strand, the energy spent on this process could, in principle, also account for strand separation when the helicase reaches a double-stranded region...
What mechanistic role do adult-born DGCs play in behavioral pattern separation? Although the gross anatomical connectivity of the DG suggests a role in pattern separation, the DG’s ability to perform this function appears to be further enhanced via its ability to incorporate new neurons. Adult-...
Because of the evidence suggesting the GMB plays a role in AD pathogenesis, therapeutic strategies targeting the GMB may be useful for modifying disease progression. One class of therapeutics that may be effective in modifying the GMB and altering disease progression is probiotics/prebiotics (Fig.2)...
What does it do or what is it involved in? What is the role of the polymerase chain reaction in DNA or RNA sequencing? (a) Describe DNA. (b) Describe the three major steps of PCR. In PCR, what would be the most likely outcome if annealing temperatures of a) 45C or b) 80C w...
What do cytoplasmic determinants do? Cytoplasmic determinants are the substances present in the egg or blastomere,determining the fate of the cells during cleavage. They also play an important role in oocyte maturation. They can be proteins, mRNA, organelles or other substances that are unevenly-di...
role in driving CRC tumorigenesis and characterizing the involvement of specific RNA cargo of EVs may shed light on such a malignant process. Similar to previous reports, this study suggests specific RNA enrichment in EVs that is selectively sorted. Furthermore, long coding and non-coding RNAs, ...
Two important classes of small RNAs regulate TEs: small interfering RNA and piwi-interacting RNA (piRNA). The first class is associated to Dicer endoribonuclease and has an important role in the control of TEs in plants (Matzke et al., 2009). piRNAs mediated the silencing through their ...
It also found that these noncoding RNA are transcribed by a class of satellite DNA, although they do not produce proteins, their regulatory role is closely related to the growth of tumor [25, 26]. Mutational characteristics in various cancers An analysis based on TCGA data shows that there ...
(clustered regularly interspaced short palindromic repeats, CRISPR). And in addition to such characteristic sequences, there are also some CRISPR-associated genes nearby. These are the series of Cas proteins that we later said play a role in cutting and integrating exogenous fragments. So we can ...