Intergenic sRNAs have been studied intensively, and it was revealed that they have important regulatory functions under many different conditions. However, the numbers of cis-antisense RNAs and of cis-sense RNAs are much higher, and thus future research will shift to concentrate on their ...
Various biotypes of endogenous small RNAs (sRNAs) have been detected in human circulation, including microRNAs, transfer RNAs, ribosomal RNA, and yRNA fragments. These extracellular sRNAs (ex-sRNAs) are packaged and secreted by many different cell types. Ex-sRNAs exhibit differences in abundance in...
Protein domains of RNA helicases that are named after the Escherichia coli homologous recombination protein RecA. Argonaute A family of proteins that bind to various non-coding RNAs, including microRNAs, and mediate RNA silencing. Transport granules Ribonucleoprotein particles containing mRNAs, RNA-binding...
The 28S, 18S, and 5.8S molecules are produced by the processing of a single primary transcript from a cluster of identical copies of a single gene. The 5S molecules are produced from a different cluster of identical genes. Totally, the eukaryotic ribosome has a Svedberg coefficient of the 80...
RNAs perform their function by forming specific structures, which can change across cellular conditions. Structure probing experiments combined with next generation sequencing technology have enabled transcriptome-wide analysis of RNA secondary structure in various cellular conditions. Differential analysis of st...
In this review, we give an overview of different fungal RNAi pathways with a focus on their mechanisms and functions. 展开 关键词: small noncoding RNA Schizosaccharomyces pombe Neurospora DOI: 10.1146/annurev-micro-092611-150138 被引量: 185 ...
During this processing three distinct steps can be resolved, and hand-over between different exonucleases appears to occur at least twice. 3 processing of snoRNAs (small nucleolar RNAs) that are excised from polycistronic precursors or from mRNA introns is also a multi-step process that involves...
Background Non-coding RNAs (ncRNAs) are an emerging focus for both computational analysis and experimental research, resulting in a growing number of novel, non-protein coding transcripts with often unknown functions. Whole genome screens in higher eukaryotes, for example, provided evidence for a sur...
The functions of short ORFs and their microproteinsMany 'non-coding' RNAs contain different types of coding sequences, which are translated into functional microproteins or peptides.doi:10.1038/s41580-020-0239-7Eytan ZlotorynskiNature Reviews Molecular Cell Biology...
Heptameric protein complex that associates with Sm sites located at the 3′ end of small nuclear RNAs (snRNAs) and telomerase RNA and stabilizes them. sno-lncRNAs A class of long non-coding RNAs (lncRNAs) that is protected from degradation by the presence of a small nucleolar RNA (snoRNA) ...