Comparative analysis of structured RNAs in indicates a multitude of different functionsClaudia StocsitsBmc Biology
The 28S, 18S, and 5.8S molecules are produced by the processing of a single primary transcript from a cluster of identical copies of a single gene. The 5S molecules are produced from a different cluster of identical genes. Totally, the eukaryotic ribosome has a Svedberg coefficient of the 80...
The functions of many regulatory RNAs depend on how their 3D structure changes in response to a diverse array of cellular conditions. In this Review, we examine how the structural characterization of RNA as dynamic ensembles of conformations, which form with different probabilities and at different ...
Protein domains of RNA helicases that are named after the Escherichia coli homologous recombination protein RecA. Argonaute A family of proteins that bind to various non-coding RNAs, including microRNAs, and mediate RNA silencing. Transport granules Ribonucleoprotein particles containing mRNAs, RNA-binding...
Through their recognition by protein complexes with enzymatic activities cross talk is established between different modifications and with other epigenetic pathways, including noncoding RNAs (ncRNAs) and DNA methylation. Here, we review the functions of histone modifications and their expoitation in the...
N6-methyladenosine (m6A) has emerged as an abundant modification throughout the transcriptome with widespread functions in protein-coding and noncoding RNAs. It affects the fates of modified RNAs, including their stability, splicing, and/or translation,
spectrumofRNAsthatarepresenttemporarilyand controlgeneexpressioninresponsetoavarietyof stimuli.Thenon-protein-codingRNAs(npcRNAs)have justifiablybeendescribedas‘thearchitectsofeukaryotic complexity’becausetheirnumberincreaseswithevolu- tionaryadvancement(5).RNA-basedmechanismsthat ...
In recent years, the discovery of functional small RNAs has brought about an unprecedented revolution within the field of molecular biology. This volume describes strategies for the discovery and validation of small RNAs. It provides a snapshot of our current understanding of the different mechanisms...
Long non-coding RNAs (lncRNAs) play important roles in cancer. They are involved in chromatin remodeling, as well as transcriptional and post-transcriptional regulation, through a variety of chromatin-based mechanisms and via cross-talk with other RNA species. lncRNAs can function as decoys, scaffol...
The major part of evolutionary "older" TEs accumulated mutations over time and fails to encode functional proteins. However, repeats have important functions also on the RNA level. Repetitive transcripts may serve as multifunctional RNAs by participating in the antisense regulation of gene activity and...