The aim of this review is to present the interest in using cytological and/or liquid biopsies as complementary biological material, or as an alternative to tissue specimens, for detection at diagnosis of new predictive biomarkers of NS-NSCLC. Keywords: lung cancer; biomarkers; cytology; liquid ...
Small-cell lung cancer (SCLC) is a deadly cancer associated with smoke exposure that has neuroendocrine (NE) cell properties and is pathologically, molecularly, biologically and clinically very different from other lung cancers. While most patients with SCLC respond initially to cytotoxic therapy, almo...
Biopsy of these tissues revealed adenocarcinoma with immunohistochemistry (IHC) positive for cytokeratins (CK) 7 and 20 as well as weak positivity for lung cancer-specific TTF-1 and Napsin-A. Positron emission tomography (PET) scan showed uptake in the distal esophagus and mediastinal/abdominal ...
Abstract When do you need to take biopsies of the liver, and what information will you get is the topic of this review on hepatocellular carcinoma (HCC). If, clinically, the differential diagnosis of HCC after imaging is suggested, a biopsy has become obligatory as a diagnostic confirmation of...
Another strategy employed to target PAX factors is to inhibit their binding activity. Grimley et al76 identified among 227 potential PAX2 inhibitors a small molecule, termed EG1 that effectively blocked PAX2-5-8 DNA binding activity and decreased the viability of cancer cells. Recently, the same...
CEA is not specific to medullary thyroid cancer. Increased CEA levels are seen, for example, in smokers and in individuals with inflammatory diseases of the gastrointestinal tract or lung disease. Because of its low specificity, serum CEA level measurement is not suitable as a screening test for...
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Positive immunostaining for TTF-1 and Napsin A, and negative staining for Thyroglobulin and PAX8 helped in the differential diagnosis and confirmed the lung primary origin of the tumour. Fine needle aspiration cytology of pulmonary papillary adeno-carcinoma mimicking papillary thyroid carcinoma Miya et ...
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Anaplastic carcinoma is considered the end point of follicular cell-derived cancer progression and—despite its heterogeneous morphology—is defined by the presence of high-grade features and lack of follicular cell differentiation [1]. The criteria for poorly differentiated carcinoma are still somewhat ...