How do we search for new instances of a motif in this sea of DNA?关键词: DNA DNA-Binding Proteins Sequence Analysis, DNA Base Sequence Gene Expression Regulation Binding Sites Molecular Sequence Data DOI: 10.1038/nbt0406-423 被引量: 346 ...
The transcription factor encoded by sll1130 has been suggested to recognize this motif to regulate heat-responsive genes. Our data suggest that HIP1 is not a regulatory element within the scp genes. Further, the presence of the high light regulatory (HLR1) motif was confirmed in scpB-E, in...
In this report, the authors identify a germline mutation in the promoter of TERT , which creates a binding motif for ETS and TCF transcription factors. CAS PubMed Google Scholar Huang, F. W. et al. Highly recurrent TERT promoter mutations in human melanoma. Science 339, 957–959 (2013)...
The alpha-helical, coiled-coil protein motif is increasingly recognized in a variety of functional classes of proteins. The pitch of a coiled coil, or rate of winding of the alpha-helices around each other, is a key determinant of both intra- and intermolecular interactions. Experimental measurem...
2020). The loss of two disulfide bonds in the eight-cysteine motif (8-CM) that is conserved among the nsLTPs causes growth inhibition in Ptd1 mutants, and Ptd1 may be important for pathways required for cell division and elongation. However, how Psd1 exerts a dominant effect for growth ...
2012). The Cas enzyme to bind to the target DNA requires a so-called protospacer adjacent motif (PAM) sequence. This PAM sequence is specific for each Cas protein. For the most commonly used SpCas9, NGG somewhat limits the choice of a target sequence. Although there are sufficient NGG ...
HIF is a heterodimeric transcription factor composed of an O2-sensitive α subunit and an O2-insensitive β subunit8. To date, three α forms (HIF-1α, HIF-2α, and HIF-3α) are known to exist. These α forms (at least the human form) contain a basic helix-loop-helix (bHLH) domai...
Pseudomonas syringae is one of the most common plant pathogens that infect the phyllosphere. P. syringae can live on the plant surface as an epiphyte. To cause disease, it enters the plant, through wounds or natural openings such as stomata, and multiplies within the apoplast. P. syringae is...
transcription 6 (STAT6), which in turn, enhances downstream CLCA1 expression and MUC5AC secretion by airway epithelial cells. Specific knockout of SAM-pointing domain-containing ETS transcription factor (SPDEF) can inhibit the production of MUC5AC in human respiratory epithelial cells, which is ...
members of theYABBYgene family have been identified [119] and are known to encode transcription factors with a zinc-finger and a helix-loop-helix motif. These includeFILAMENTOUS FLOWER(FIL),YABBY2(YAB2),YAB3, andYAB5, which are expressed in leaf primordia, andCRABS CLAW(CRC) andINNER NO ...