Transcription Factor-Target Gene Mapping Enhanced by Integrating Motif Search, Function Annotation and Expression DataBiosensorPS-II particlesCyanobacteriaSpectral PropertiesElectrochemical and nanogravimetric DNA-hybridization biosensors have been developed for sensing single mismatches in the probe-target ssDNA ...
The release of ChIP-seq data from the ENCyclopedia Of DNA Elements (ENCODE) and Model Organism ENCyclopedia Of DNA Elements (mod ENCODE) projects has significantly increased the amount of transcription factor (TF) binding affinity information available to researchers. However, scientists still routinely...
AP1 became one of the paradigms for growth factors and signalling controlled transcription factor. Other factors include the octamer motif binding proteins, Oct 1 and Oct2, which also bind to the immunoglobulin gene promoters (Sturm, Das, and Herr, 1988; Clerc et al., 1988), PEA3 (Polyoma...
POBO can be used to detect, compare and verify predetermined transcription factor binding site motifs in the promoters of one or two clusters of co-regulated genes. The program calculates the frequencies of the motif in the input promoter sets. A bootstrap analysis detects significantly over- or...
The octamer motif binds factor Oct-1 or Oct-2 which stimulates U6 or 7SK transcription both in vivo and in vitro.178,179 Binding of Oct-1 or Oct-2 to the distal element stimulates or stabilizes PTF binding to the basal promoter.180,181 Unlike other TATA-containing class III genes, th...
Yu et al, 2021 report that the R2R3-MYB transcription factor GmTDF1-1 is crucial for the anther development in soybean. A loss of this gene function by a point mutation resulted in male sterility. There is a very similar TDF1-2 gene, but insufficient expression prevents a compensation of...
Although discriminative motif discovery (DMD) methods are promising for eliciting motifs from high-throughput experimental data, due to consideration of computational expense, most of existing DMD methods have to choose approximate schemes that greatly restrict the search space, leading to significant loss...
(PAMPs) switch on the expression of various transcription factor genes. Messages generated by PAMP-PRR signaling complex are sensed by calcium ion, which acts as a signal carrier. Calcium signatures are recognized by different calcium sensors to transduce calcium-mediated signals into downstream events...
The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control. The Hippo (Hpo) signaling pathway governs cell growth, proliferation, and apoptosis by controlling key regulatory genes that execute these processes; howev... Z Lei,F Ren,Q Zhang,... - 《Develo...
An obvious factor driving promiscuity are electrostatic interactions, which contribute to the stabilization of the specific binding site42, but also promote nonspecific binding to any other site along a given DNA molecule3. The 3D structure of the EngHD-DNA complex40,43highlights attractive electrostat...