"This research significantly advances our understanding of metformin's mechanism of action," Chandel said. "While millions of people take metformin, understanding its exact mechanism has been a mystery. This study helps explain that metformin lowersblood sugarby interfering with mitochondria in cells."...
Its main mechanism of action appears to be stimulation of the AMP-dependent protein kinase, which is a sensor of the energetic status of the cells and a major regulator of cellular and whole-body energy homeostasis, coordinating metabolic pathways in order to balance nutrient supply with energy ...
1.Dragamestianos C, Messini CI, Antonakis PT, Zacharouli K, Kostopoulou E, Makrigiannakis A, Georgoulias P, Anifandis G, Dafopoulos K, Garas A, Daponte A, Messinis IE. The effect of metformin on the endometrium of women with polycystic ovary syndrome[J]. Gynecol Obstet Investig. 201...
Acute gouty arthritis is a major and increasing public health problem given the substantial rise in gout prevalence over the last two decades [1]. Acute gout flares are the major contributor to gout-specific impaired health-related quality of life [2]. In this context, flares can be complex ...
aChronic insulin exposure of Hep G2 cells induces the downregulation of insulin signal transduction via PI3K pathway. The effect of metformin on insulin signaling transduction represent a primary mechanism of metformin action in insulin resistant state. 酷G2细胞慢性胰岛素曝光通过PI3K路导致胰岛素信号转导...
Linagliptin (TrajentaR, TradjentaTM, TrazentaTM, TrayentaTM) is an oral, highly selective inhibitor of dipeptidyl peptidase-4 and is the first agent of its class to be eliminated predominantly via a nonrenal route. Linagliptin is indicated for once daily use for the treatment of adults with ...
The same mechanism of action can alleviate cholestasis-related itching. Cholestasis is caused by the impaired flow of bile from the liver to the intestines, leading to a buildup of bile acids in the blood. These acids irritate nerves and cause itching. By lowering bile acid levels, itching is...
Importantly, remission can also be achieved in clinical practice by the use of short-term, intensive pharmacotherapy regimens (alternating approaches to either diet or surgery). As published by these authors (RAD), the EDICT study showed that a regimen of metformin, pioglitazone and exenatide achiev...
Intestinal motor and sensory functions are influenced by the immune system to activate a mechanism of defense from noxious agents in the intestinal lumen[189]. Mice infected with Trichinella spiralis develop muscle hyper-contractility in the gut[190] but these effects disappear in animal models of ...
Our comprehension of the mechanism between BA and chronic metabolic diseases is expanding, and many new research results have emerged in recent years. This paper provides an overview of the mechanisms involved in the synthesis and metabolism of bile acids, along with exploring their role as ...