[translate] aThe effect of metformin on insulin signaling transduction represent a primary mechanism of metformin action in insulin resistant state. metformin的作用在胰岛素信号转导在胰岛素抗性状态代表metformin行动一个主要机制。 [translate] 英语翻译 日语翻译 韩语翻译 德语翻译 法语翻译 俄语翻译 阿拉伯语翻译...
The effect of metformin on insulin signaling transduction represent a primary mechanism of metformin action in insulin resistant state. 酷G2细胞慢性胰岛素曝光通过PI3K路导致胰岛素信号转导的downregulation。 metformin的作用在胰岛素信号转导在胰岛素抗性状态代表metformin行动一个主要机制。 [translate] ...
Metformin not only inhibits the basal lipolysis simulated by high glucose, but also suppresses the high glucose-enhanced lipolysis response to TNF-alpha or isoproterenol. The antilipolytic action in adipocytes could be the mechanism by which cellular action by metformin reduces systemic FFA ...
Role of AMP-activated protein kinase in mechanism of metformin action. J. Clin. Invest. 108, 1167–1174. https://doi.org/10.1172/JCI13505 (2001). Article CAS PubMed PubMed Central Google Scholar Cade, W. T. et al. Myocardial glucose and fatty acid metabolism is altered and associated ...
As a very promising immunotherapy, PD-1/PD-L1 blockade has revolutionized the treatment of a variety of tumor types, resulting in significant clinical efficacy and lasting responses. However, these therapies do not work for a large proportion of patients initially, which is called primary resistance...
The mechanism of cause and effect relation between accelerated biological maturation and PH is not known. As suggested by Lever and Harrap, faster biological maturation is associated with greater exposure to growth factors, sex hormones and especially androgens, and visceral fat deposition [61]. ...
By addressing the hypothesis, this study may reveal the relationship between FoxO1, insulin and PI3K-Akt-mTOR signal pathway, provide a reference for the goose fatty liver (foie gras) formation mechanism. and open a new approach to preventing the occurrence of nonalcoholic steatohepatitis suffered ...
The exact mechanism of the antiviral effect of statins is still unclear, which may be associated with the inhibition of geranylgeranylation of cellular proteins52. On the basis of the above benefits as well as the proven efficacy and safety of statins in patients with chronic liver disease53, ...
Hyperprolactinemia causes amenorrhea by a negative feedback mechanism to the anterior pituitary that results in decreased production of FSH and LH. Technical Note • Prolactin secretion is under the influence of thyroid-releasing hormone (TRH), which is secreted by the pituitary in response to ...
Although our data do not include patient-reported outcomes, the added convenience of telehealth-enabled home blood pressure readings could represent a potential mechanism of how telehealth facilitates management of hypertension. Our findings add to the literature of telehealth as an effective m...