Fucosyltransferase 6/7-mediated fucosylation of cell surface type 2 sialylLacNAc drives the formation of sialyl Lewis X (sLeX), which is normally decreased on CAR T-cells as a consequence of cell culture expansion. Stable sLeXdisplayed on the cell membrane allows for enhanced binding to the endot...
Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe J. Biol. Chem., 277 (33) (2002), pp. 29945-29952 Google Scholar Park et al., 2006 K. Park, S. Jeon, S. Kim, Y. Bahk, S. Holmen, B. Williams, K. Chung, Y. Surh, K. Choi APC inhibits ERK pathway ...