What does synthetic lethality mean? Listen to pronunciation. (sin-THEH-tik lee-THA-luh-tee) Describesa situation in which mutations (changes) in two genes together result in cell death, but a mutation in either gene alone does not.
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abaidu is cam chat too baidu也是凸轮闲谈[translate] amccmmc mccmmc[translate] aHams 火腿[translate] atheir synthetic lethality with BRCA mutations. 他们的综合性摧毁效能以BRCA变化。[translate] agirls section 女孩部分[translate] aThis is the acoustic characteristic which differentiates the acoustic ran...
1️⃣ One particularly exciting field is perturbative biology. Understanding the outcomes of perturbations can lead to advancements in cell reprogramming, target discovery, and synthetic lethality, among others. In 2023, GEARS applies GNN to gene perturbational relational graphs and...
These compounds can also be classified as retinoids, including compounds with a common structure of four isoprenoid units being of either a natural or synthetic origin. Biological function Vitamin A is the primary signaling molecule in the visual process in which 11-cis-retinal, a component of ...
Synthetic lethal therapies for cancer: what's next after PARP inhibitors? The genetic concept of synthetic lethality has now Alan,Ashworth,Christopher,... - 《Nature Reviews Clinical Oncology》 被引量: 16发表: 2018年 Special Section: Security -- What's Next for Drinking Water Security? (PDF)...
BLM (Bloom syndrome protein) is a RECQ-family helicase involved in the dissolution of complex DNA structures and repair intermediates. Synthetic lethality ... X Chen,YI Ali,CE Fisher,... - 《Elife Sciences》 被引量: 0发表: 2021年 I'll Be Home with My Kids for Christmas ; Uplifting Prom...
Studies have found that METTL16 knockdown can cause a significant decrease in the installation of m6A/A [17], and can even lead to embryonic lethality in mice [19]. While there is significant evidence that METTL16 is involved in both cancer and non-cancer diseases, the role that it plays...
Synthetic lethal therapies for cancer: what's next after PARP inhibitors? The genetic concept of synthetic lethality has now been validated clinically through the demonstrated efficacy of poly(ADP-ribose) polymerase (PARP) inhibitors for the treatment of cancers in individuals with germline loss-of-fu...