The concept of synthetic lethality has been widely applied to identify therapeutic targets in cancer, with varying degrees of success. The standard approach normally involves identifying genetic interactions between two genes, a driver and a target. In reality, however, most cancer synthetic lethal ...
Although chemotherapy remains widely used in cancer care, combinations and targeted approaches are starting to redefine the treatment of some tumors. Engine Biosciences’ network biology approach is well suited to the identification of drug combinations and gene combinations that enable synthetic lethality,...
Large deletions of chromosomal regions can provide opportunities for cancer treatment. In particular, codeletion of passenger genes in proximity to tumour suppressors can lead to collateral lethality and create potential vulnerabilities specific to those cancers15,16,17,18. These codeleted genes may have...
Cancer remains a significant challenge in modern medicine, prompting continuous exploration for novel therapeutic strategies. Understanding the complex molecular mechanisms driving cancer progression is essential for developing effective treatments. The
As oncogenes can generate secondary dependencies, targeting of these vulnerabilities may result in synthetic lethality that is oncogene specific. Our studies uncover a selective dependency of KMT2A-rearranged (KMT2A-r) leukemias on proteostasis and specifically immunoproteasome function. This interferon-...
Table S1. PAF expression in human lung cancer, related to Figure 1 Table S2. GSEA using differentially expressed genes (KP and H1792, shCtrl versus shPaf), related to Figure 4 Table S3. PAF-DREAM targets and their correlation with poor clinical outcomes in LUAD, related to Figure 4 Tabl...
cancertherapeuticssynthetic lethalitysmall molecule inhibitorsantisense oligonucleotidesMutations in cohesin genes have been described in numerous solid cancers and hematologic malignancies; subsequent experimental evidence has linked these mutations with carcinogenesis. Areas covered: In this review, we present ...
②Nature:Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers WRN抑制剂HRO761在微卫星不稳定性(MSI)癌症中具有合成致死性 DOI: 10.1038/s41586-024-07350-y ③Cell Death & Disease:Annexin A2 combined with TTK accelerates esophageal cancer progression via the Akt/mTOR signaling path...
ATP-dependent chromatin remodelers are commonly mutated in human cancer. Mammalian SWI/SNF complexes comprise three conserved multisubunit chromatin remodelers (cBAF, ncBAF and PBAF) that share the BRG1 (also known as SMARCA4) subunit responsible for the
Histone lysine succinylation, an emerging epigenetic marker, has been implicated in diverse cellular functions, yet its role in cancer drug resistance is not well understood. Here we investigated the genome-wide alterations in histone 3 lysine 23 succiny