2) Intracellular signalling molecules which are important in transmitting the actions of inflammatory mediators and include protein kinase A and C, Src kinase, mitogen-activated protein kinases and the membrane lipid PIP2; and 3) Ion channel targets of intracellular signalling which ultimately cause se...
AR: Membrane associated androgen receptor; CREB: cAMP response element binding protein; DAG: Diacylglycerol; GPCR: G-protein-coupled receptor; IP3: Inositol trisphosphate; PLC: Phospholipase C; SRC: Src kinase; RAS: RasGTPase protein; +: Indicates positive effect on activation. ...
What is integration in cell signaling? What is the EGF receptor in cell signaling? What are hydrophilic signaling molecules? What is SRC in cell signaling? What does Ras do during tyrosine kinase cell signaling? What is the JAK-STAT pathway for cell signaling?
Protein kinase C epsilon is overexpressed in primary human non-small cell lung cancers and functionally required for proliferation of non-small cell lung cancer cells in a p21/Cip1-dependent manner. Cancer Res 2007; 67: 6053–6063. CAS PubMed Google Scholar Benavides F, Blando J, Perez CJ...
2009, Cellular and Molecular Life Sciences Interaction of transient receptor potential vanilloid 4, integrin, and Src tyrosine kinase in mechanical hyperalgesia 2008, Journal of Neuroscience The collagen family members as cell adhesion proteins 2007, BioEssays View all citing articles on Scopus ...
Dasatinib is an oral dual BCR/ABL and Src family tyrosine kinase inhibitor approved for use in patients with chronic myelogenous leukemia (CML). The main targets of Dasatinib, are BCRABL, SRC, Ephrins and GFR. Dasatinib is used to treat a certain type of chronic myeloid leukemia (CML; a ...
Thus, it is likely that the SHPS-1/CD47 interaction inhibits alpha(IIb)beta(3)-mediated outside-in signaling by interfering with the downstream pathway of FAK. Taken together, our data suggest that SHPS-l negatively regulates platelet function via CD47, especially alpha(IIb)beta(3)-Mediated ...
Protein kinase C epsilon is overexpressed in primary human non-small cell lung cancers and functionally required for proliferation of non-small cell lung cancer cells in a p21/Cip1-dependent manner. Cancer Res 2007; 67: 6053–6063. CAS PubMed Google Scholar Benavides F, Blando J, Perez CJ...
(AZD8330, trametinib, cobimetinib), one PI3 kinase inhibitor (taselisib), one dual inhibitor of EGFR and ErbB2 tyrosine kinases (AV-412), one selective Src kinase inhibitor (saracatinib), one telomerase inhibitor (costunolide), and two vitamin D receptor agonists (tacalcitol and alfacalcidol)....
Jaktinib is a Janus kinase (JAK) inhibitor with potential therapeutic applications in various inflammatory and fibrotic diseases [161,162]. Jaktinib may influence immune response in the lungs and attenuate the activity of immune cells which contribute to fibrosis [163,164]. The safety profile of...