Medical imaging related knowledge and skills are widely used in clinical practice. However, radiology teaching methods and resultant knowledge among medical students and junior doctors is variable. A systematic review and meta-analysis was performed to compare the impact of different components of radiolo...
Nephronophthisis literally means “damage to the nephrons.” It is an autosomal recessive disorder that represents the most common monogenetic cause of renal insufficiency in children and young adults. It is enormously genetically heterogeneous, i.e., mutations in at least 13 different genes have be...
The impact of molecular pathology in these tumors is multifaceted and bears diagnostic, prognostic, and predictive implications although its use in the clinical practice is not completely assessed. Genomic profiling data claim that genetic alterations in poorly differentiated and anaplastic thyroid carcinoma...
We understand plan quality in radiotherapy as the clinical suitability of the delivered dose distribution that can be realistically expected from a treatment plan. Plan quality is commonly assessed by evaluating the dose distribution calculated by the treatment planning system (TPS). Evaluating the 3D ...
Currently, the confirmatory phase 3 clinical trial (NCT04303780, Codebreak 200) is evaluating the efficacy of sotorasib against docetaxel for second line metastatic NSCLC. There are other ongoing trials evaluating sotorasib as a monotherapy or in combination in KRAS G12C mutated lung cancer or ...
This fat storage is not without consequences. In fact, hepatic steatosis con- tributes to the progression toward liver fibrosis [3]. There are two main types of fatty liver disease, alcoholic fatty liver disease (AFLD) and nonalcoholic fatty liver disease (NAFLD). In recent years, there have...
Loss of the Pten gene resulted in an enhanced PI3K signaling pathway which was indicated by an increase in phosphorylated Akt (p-Akt). Akt is known to mediate the activation of the mammalian target of rapamycin complex 1 (mTORC1) through multiple mechanisms, as an upstream regulator of mTOR...
In this review, I report experimental findings from several studies aiming to identify promising therapeutic strategies for treating PF developed in PCM. Keywords: Paracoccidioides spp.; paracoccidioidomycosis; pulmonary fibrosis; therapy; treatment; itraconazole 1. Introduction Pulmonary fibrosis (PF) is ...