STUDY SELECTION: Discriminatory accuracy studies of breast cancer risk assessment methods; randomized clinical trials of tamoxifen, raloxifene, and aromatase inhibitors for primary breast cancer prevention; studies of medication adverse effects. DATA EXTRACTION AND SYNTHESIS: Investigators abstracted data on me...
Randomized controlled trial evidence comes in the form of the AJAX, ECAR, and IMPROVE trials, with the latter mirroring current clinical practice most closely. IMPROVE has shown that endovascular surgery for rAAA is as effective as open surgical repair, allows for shorter hospital stays, offers a...
Evidence-based medicine, systematic reviews, and guidelines in interventional pain management: Part 2: Randomized controlled trials. Evidence-based medicine (EBM) is a shift in medical paradigms and about solving clinical problems, acknowledging that intuition, unsystematic clinical expe......
One example of an interventional study is a randomized control trial (RCT). During a randomized control trial, human subjects are chosen at random to receive an intervention. Generally, participants are arbitrarily placed into one of two groups: the experimental group receiving the intervention that ...
Consent and randomized clinical trials: are there moral or design problems? The purpose of this paper is to examine whether randomized clinical trial (RCT) methods are necessarily morally problematic. If they are intrinsically prob... Kopelman - 《Journal of Medicine & Philosophy》 被引量: 14发表...
Regenerative medicine, such as the use of mesenchymal stem cells or platelet-rich plasma, in intradiscal disc degeneration has shown preclinical and clinical positive results. Randomized clinical trials studying the potential of MSCs intradiscal injection have not been conducted, and PRP effect has bee...
What is exploratory research? What is a randomized experiment? What is cytotoxicity testing? What is diagnostic medicine? What is a systematic sample? What is the American Society for Clinical Pathology? What is forensic pathology? What is forensic toxicology?
What is a cluster randomized design? A cluster randomised trial (CRT) isa randomised controlled trial in which pre-existing groups, called clusters, of individuals are randomly allocated to treatment arms. For example, clusters may be clinical practices or schools where the individuals are patients ...
The prospective randomized clinical trial (RCT) is seen by many to be the 'gold standard' for analysing treatment outcome and the only valid source of clinical data. In orthodontics, most RCTs have been designed to resolve the controversy surrounding the ability of functional appliances to signifi...
There are several types of clinical trials. A single-arm trial has no comparison group. A randomized controlled trial (RCT) has two groups of patients, each of which may receive either the test treatment or a harmless placebo. Depending on the trial design, the allocation of the drug vs. ...