In the acquired long QT syndrome, torsades de pointes (TP) is invariably preceded by pauses or bradycardia. Thus, it has been proposed that out-of-hospital initiation of drugs that prolong repolarization should be safe in patients with permanent pacemakers. However, a minimal protective pacing ...
In any case, a proper evaluation of the benefit-risk ratio is mandatory when findings indicate that a new compound may prolong repolarization. 展开 关键词: action potential QT prolongation drug development DOI: 10.1016/S1520-765X(01)90013-6 ...
Following an abrupt change in heart rate (HR), QT adaptation is achieved within a delayed time frame. The exclusion of electrocardiograms (ECGs) showing rapid HR changes influences the level of a drug-induced QT prolongation. Continuous 12-lead ECG-Holter monitoring was performed in 31 healthy ...
Methadone maintenance, QTc and torsade de pointes: who needs an electrocardiogram and what is the prevalence of QTc prolongatio?. Drug Alcohol Rev. 2011;30:388-96.Mayet S, Gossop M, Lintzeris N, Markides V, Strang J. Methadone maintenance, QTc and torsade de pointes: who needs an ...
Is amiodarone contraindicated in torsades? cessation of all QT-prolonging medications Evidence regarding which drugs cause torsades is extremely murky. In some cases it seems that drugs have been incorrectly maligned (e.g. azithromycin, olanzapine). Which drugs prolong QT the most? Drugs that cause...
(mutation in KvLQT1/IKs) and type 2 (mutation in HERG/IKr) have longer QT intervals and a higher risk for TdP and SCD than men [20–22]. Moreover, during adulthood, female gender is a major independent risk factor for SCD independent of genotype or the location of the mutation within...
Additionally, NAs impair the functioning of plasma cholinesterases, which may further prolong the action of succinylcholine by decreasing metabolism. If succinylcholine is utilized, it should be administered in reduced doses and used with caution. Gulf War soldiers who were prophylactically treated ...
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” If FP-SP conduction occurs repetitively, frequent PJCs cause ventricular rates to be twice that of sinus rhythm. At other times, sinus rhythm may conduct with abruptly changing PR intervals, when antegrade conduction is intermittently blocked in the FP owing to retrograde concealment from the ...
Considering the larger size of the stainless- steel tanks used for storage, the interfaces of gas–liquid and solid–liquid are fewer than those in pottery jars, and will prolong the time to the maturity of Baijiu [83]. Besides, the tight arrangement of molecules in the tank structure, ...