In the acquired long QT syndrome, torsades de pointes (TP) is invariably preceded by pauses or bradycardia. Thus, it has been proposed that out-of-hospital initiation of drugs that prolong repolarization should be safe in patients with permanent pacemakers. However, a minimal protective pacing ...
In any case, a proper evaluation of the benefit-risk ratio is mandatory when findings indicate that a new compound may prolong repolarization. 展开 关键词: action potential QT prolongation drug development DOI: 10.1016/S1520-765X(01)90013-6 ...
Clinical observations: sex differences and sex hormone effects in long-QT syndrome The inherited LQTS is a heterogeneous arrhythmogenic disease, in which an impaired cardiac repolarization pre- disposes patients to torsade-de-pointes (TdP) tachycardia, syncopes, and sudden cardiac death (SCD) [19]....
cessation of all QT-prolonging medications Evidence regarding which drugs cause torsades is extremely murky. In some cases it seems that drugs have been incorrectly maligned (e.g. azithromycin, olanzapine). Which drugs prolong QT the most?
For this reason, the citizens of the area, decided to protect the artwork by implementing a physical barrier, i.e., a plexiglass transparent panel, with the intention of preserving it and trying to prolong its durability. From a social point of view, this solution represents a turning point...
Many antiarrhythmic drugs, psychiatric drugs, anti-infectives, and antihistamines prolong the QT interval and pose a risk ofTdeP. Importantly, QT prolongation does not appear to be a class effect; that is, there can be a marked variation in the magnitude of QT effect among drugs with otherwise...
Additionally, NAs impair the functioning of plasma cholinesterases, which may further prolong the action of succinylcholine by decreasing metabolism. If succinylcholine is utilized, it should be administered in reduced doses and used with caution. Gulf War soldiers who were prophylactically treated ...
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” If FP-SP conduction occurs repetitively, frequent PJCs cause ventricular rates to be twice that of sinus rhythm. At other times, sinus rhythm may conduct with abruptly changing PR intervals, when antegrade conduction is intermittently blocked in the FP owing to retrograde concealment from the ...
This is unnerving is what I was thinking. But after a couple of hours of roaming through leaves, I felt a new calm. When it was time to head in, I was torn between desperately wanting to talk to somebody—anybody—and wanting to prolong the me-myself-and-the-woods time. (Also on ...